pain in icu patients should be managed effectively and safely. fentanyl and paracetamol are used frequently in icu. however experience using iv paracetamol in the setting of critically ill patients is limited. we evaluated the analgesic effect and adverse reactions of intravenous paracetamol compared to fentanyl in icu patients with mild to moderate pain. forty patients in a general icu were ra...

though intravenous (iv) magnesium sulphate (mgs04) has additive effect to beta-2 agonists, its additive benefit in face of combination therapy with beta-2-agonists and ipratropium (standard therapy of severe acute exacerbation of asthma) remains unaddressed. the aim of this investigation was to evaluate the role of iv mgso4 when used as an adjunct to standard therapy of severe exacerbations of ...

BACKGROUND High oral bioavailability of antimicrobial agents can result in the replacement of intravenous (IV) therapy with oral therapy when a patient meets defined clinical criteria. However, few studies have evaluated the effects of switching antibiotic administration route in Japan, especially for linezolid. This study evaluated an IV-to-oral antibiotic switching program for linezolid treat...

BACKGROUND Switch therapy is a management approach combining early discontinuation of intravenous (IV) antibiotics, switch to oral antibiotics, and early hospital discharge. This analysis compares switch therapy using tigecycline versus levofloxacin in hospitalized patients with community-acquired pneumonia (CAP). METHODS A prospective, randomized, double-blind, Phase 3 clinical trial; patien...

the present work describes the studies on the coordination behaviour of 4[n-(benzalidene) amino]antipyrine semicarbazone (baaps) (i), 4[n-(furfural)amino]antipyrine semicarbazone (ffaaps) (ii) and 4[n-(cinnamalidene)amino]antipyrine semicarbazone (caaps) (iii) in presence of dimethyl sulfoxide (dmso) or diphenyl sulfoxide (dpso) towards th4+ and uo22+ salts. all the complexes were isolated in n...

The objective of this study was to assess how different modes steroid therapy affect hearing preservation in Partial Deafness Treatment group patients. In study, the consisted 46 (24 women, 22 men; aged 18-78 years) cochlear implant patients divided into 3 subgroups. first subgroup (N = 13), underwent standard intravenous (IV) following implantation. second 16), prolonged treatment with a combi...

STUDY OBJECTIVE To determine the efficacy, safety, and economic benefit of continuous IV infusion of furosemide as a treatment modality for elderly patients with class IV heart failure. DESIGN Prospective trial of consecutively admitted elderly patients > 65 years old with class IV heart failure. SETTING A single cardiovascular service in a university medical center. PATIENTS Seventeen ma...

筋萎縮性側索硬化症（ALS）は10％が家族歴を有する家族性ALSである．本邦における原因遺伝子はSOD1，FUSの順に多く，欧米ではC9orf72が最大である．これら変異遺伝子発現を転写レベルで抑制するアンチセンスオリゴヌクレオチド（ASO）薬の開発が進んでいる．さらに孤発性ALSにおいても，ATXN2などの疾患感受性遺伝子の配列異常が同定され，前臨床試験でASOの有効性が報告されている．