Adenophostins A and B, which are metabolic products of the fungus Penicillium brevicompactum, are potent agonists at the D-myo-inositol-1,4,5-trisphosphate [Ins(1,4,5)P3] receptor. In the current study, adenophostin A was approximately 50-fold more potent than Ins(1,4,5)P3 at both releasing Ca2+ from the intracellular stores of permeabilized platelets and displacing [3H]Ins(1,4,5)P3 from its re...

Infantile nystagmus syndrome (INS) is an important clinical diagnosis because it is a common presenting sign of many ocular, neurologic, and systemic diseases. Although INS has been studied for more than a century, its diagnosis and treatment remains a challenge to clinicians because of its varied manifestations and multiple associations, and its pathogenesis continues to rouse considerable sci...

For the first time a dual pathway for dephosphorylation of myo-inositol hexakisphosphate by a histidine acid phytase was established. The phytate-degrading enzyme of Klebsiella terrigena degrades myo-inositol hexakisphosphate by stepwise dephosphorylation, preferably via D-Ins(1,2,4,5,6)P5, D-Ins(1,2,5,6)P4, D-Ins(1,2,6)P3, D-Ins(1,2)P2 and alternatively via D-Ins(1,2,4,5,6)P5, Ins(2,4,5,6)P4, ...

We used lightweight formal modeling and automatic analysis to explore and correct the design and implementation of the Intentional Naming System (INS). INS is a new scheme for resource discovery and service location in dynamic networks. We constructed a model of INS in Alloy, a lightweight relational notation, and analyzed it with the Alloy Analyzer (AA), a fully automatic simulation and checki...

In bovine adrenal microsomes, Ins(1,4,5)P3 binds to a specific high-affinity receptor site (Kd = 11 nM) with low affinity for two other InsP3 isomers, Ins(1,3,4)P3 and Ins(2,4,5)P3. In the same subcellular fractions Ins(1,4,5)P3 was also the most potent stimulus of Ca2+ release of all the inositol phosphates tested. Of the many inositol phosphates recently identified in angiotensin-II-stimulate...

By JOHN E. LUCAS, M.D. AND ALBERT B. HAGEDORN, M.D. T HE ORAL USE of iroms ins tise treatmemst of irons deficienicv ansemia has heens well established! amid documensted. However, the paremsteral use of this metal ins the treatment of hypochromic ansemia dine to irons demmcienscy has, ins the past-, been limited by the inscidemsce of toxic reactionss si-hems ansy hut suboptimal doses of the prep...

To improve the accuracy and robustness of inertial navigation systems (INS) for wheeled robots without adding additional component cost, we propose Wheel-INS, a complete dead reckoning (DR) solution based on wheel-mounted microelectromechanical system (MEMS) measurement unit (IMU) in this article. There are two major advantages mounting IMU to center non-steering wheel. Firstly, gyroscope outpu...

compelling evidence suggests that the oxidative stress plays a key role in the pathophysiology of cardiovascular disease (cvd). superoxide dismutase (sod) enzymes play a major role in detoxification of reactive oxygen species and protection against oxidative stress. we examined the possible association between a 50-bp insertion/deletion in the sod1 promoter 1684-bp upstream of the sod1 atg with...

Stimulation of [3H]inositol-prelabelled rat cerebral-cortex slices with carbachol results in the accumulation of four [3H]inositol bisphosphate isomeric species, Ins(1,3)P2, Ins(1,4)P2, Ins(3,4)P2 and Ins(4,5)P2. Although the last isomer ran as a minor peak on h.p.l.c., its accumulation was dramatically enhanced in the presence of Li+ (1 mM), such that at 30 min it represented almost 35% of the...

With regard to a marine safety system, large vessels are generally loaded with INS (Integrated Navigation System). But although small and medium-sized ships are exposed to safety accidents in the sea, they are not carrying proper navigation devices and equipment. Accordingly, in order to develop INS for small and medium-sized ships(s-INS), an existing INS has newly been organized and integrated...