thyroid scintigraphy has been helpful in detecting and evaluation of thyroid nodules. sodium pertechnetate tc-99m is the most commonly used radionuclide for thyroid imaging because of its general availability, favorable dosimetric characteristics and low cost. but, there are reports of occasional disparity in isotope uptake in lesions compared with radioiodide. in order to determine percentage ...

Stable isotope labeling (SIL) techniques have the potential to enhance different aspects of liquid chromatography-high-resolution mass spectrometry (LC-HRMS)-based untargeted metabolomics methods including metabolite detection, annotation of unknown metabolites, and comparative quantification. In this work, we present MetExtract II, a software toolbox for detection of biologically derived compo...

The determination of I in environmental samples at ultratrace levels is very difficult by ICP-MS due to a high noise caused by Xe impurities in argon plasma gas (interference of Xe), possible IH2 1 interference and an insufficient abundance ratio sensitivity of the ICP mass spectrometer for I/I isotope ratio measurement. A sensitive, powerful and fast analytical technique for iodine isotope rat...

RATIONALE Dissolved sulfur species are of significant interest, both as important substrates for microbial activities and as key intermediaries in biogeochemical cycles. Species of intermediate oxidation state such as sulfite, thiosulfate, and thiols are of particular interest but are notoriously difficult to analyze, because of low concentrations and rapid oxidation during storage and analysis...

In higher eukaryotes many genes encode protein isoforms whose properties and biological roles are often poorly characterized. Here we describe systematic approaches for detection of either distinct isoforms, or separate pools of the same isoform, with differential biological properties. Using information from ion intensities we have estimated protein abundance levels and using rates of change i...

Ultrasonic slurry sampling electrothermal vaporization isotope dilution inductively coupled plasma mass spectrometry (USSETV-ID-ICP-MS) has been applied to the determination of Cu, Zn, Cd and Pb in several ®sh reference samples. NH4NO3 was added to the sample solution to work as a modi®er. Since the sensitivity of the elements studied in ®sh slurry and aqueous solution was quite different, isot...