The induction of apoptosis by 66 alkaloids of the quinoline, quinolizidine, pyrrolizidine, isoquinoline, indole, terpene, tropane, steroid, purine, and piperidine type, of 9 cardiac glycosides, 11 non-protein amino acids and 10 further secondary metabolites was assayed in HL-60 cell cultures and measured by quantification of the subdiploid DNA content by flow cytometry, detection of DNA fragmen...

The inhibitory activity of Coptis chinensis rhizome-derived material was evaluated against sortase, a bacterial surface protein anchoring transpeptidase, from Staphylococcus aureus ATCC 6538p and compared to that of four commercially available isoquinoline alkaloids. The biologically active constituent of C. chinensis extract was characterized as the isoquinoline alkaloid, berberine chloride, b...

the isolation and characterization of two new isoquinoline alkaloids, dehydropuntarenine and dehydrosaulatine, obtained during the column chromatography of an alkaloidal fraction from the roots of b. actinacantha (berberidaceae) are described.

UNLABELLED Tetrahydropapaveroline and reticuline, isoquinoline alkaloids, were purified and identified in the pedal ganglia of the marine mollusk Mytilus edulis. OBJECTIVES To determine the presence of tetrahydropapaveroline and reticuline, isoquinoline alkaloids, in animal tissues previously shown to express opiate receptors. METHODS AND RESULTS This was achieved by high performance liquid...

Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and dehydrocorybulbine. The tertiary alkaloids were further analyzed by chiral HPLC to determine the ratios of d-and l-isomers. The isolated compounds were screened for ...

[reaction: see text] Palladium-catalyzed intramolecular carbon-carbon bond formation of aryl halides and amide-enolates gave 4-arylisoquinoline derivatives in good yields, which were further converted into the isoquinoline alkaloids cherylline and latifine.

The isolation and characterization of two new isoquinoline alkaloids, Dehydropuntarenine and Dehydrosaulatine, obtained during the column chromatography of an alkaloidal fraction from the roots of B. Actinacantha (Berberidaceae) are described.

To find new anthelmintics against parasites living in host tissues, we used an in vitro assay to screen isoquinoline alkaloids for nematocidal activity on the larva of dog roundworm, Toxocara canis. To evaluate the efficacy of anthelmintics in vitro, Tsuda et al. previously introduced the concept of Relative Mobility (RM) of Toxocara larvae. After improvement of the assay system using image dat...