Objective: Ziprasidone, aripiprazole, blonanserin, cyamemazine, and nemonapride are atypical antipsychotic drugs used for the treatment of schizophrenia. This study aimed to identify effects these in mice isolated bladder using organ bath systemMaterials Methods: The were injected intraperitoneally with 21 days. investigated on isoproterenol-induced relaxation responses carbachol-induced contra...

Objective: The bladder normally shows no contractility or activity during the filling phase. In overactive urinary bladder, spontaneous contractions and detrusor instability are seen in phase incontinence occurs. This study aims to demonstrate effects of first-generation antipsychotic haloperidol second-generation antipsychotics olanzapine, risperidone, clozapine on mice isolated using organ ba...

Jin YT, Hasebe N, Matsusaka T, Natori S, Ohta T, Tsuji S, Kikuchi K. Magnesium attenuates isoproterenol-induced acute cardiac dysfunction and -adrenergic desensitization. Am J Physiol Heart Circ Physiol 292: H1593–H1599, 2007. First published November 17, 2006; doi:10.1152/ajpheart.00985.2006.—Sympathetic nervous activation is a crucial compensatory mechanism in heart failure. However, excess c...

The beta-adrenergic receptor agonist isoproterenol exerts growth-promoting effects on salivary glands. In this study, activation of ERKs, members of the mitogen-activated protein kinase family, by isoproterenol was examined in a human salivary gland cell line (HSY). Immunoblot analysis indicated that isoproterenol (10(-5) M) induced transient activation of ERK1/2 (4.4-fold relative to basal at ...

The objective of the study aims to evaluate the combined protective effects of coenzyme Q10 and magnesium sulphate on isoproterenol induced myocardial damage in rats. CoenzymeQ10 (50 mg/kg) and magnesium sulphate (10 mg/kg) were administered orally to wistar rats in individual or in combination for 30 days.  At the end of this period, rats were administered isoproterenol (85 mg/kg i.p.) intrape...

Isoproterenol infusion during cardiac catheterization as a simulator of exercise was evaluated with hemodynamic studies in children with pulmonary (15) or aortic (8) valve stenosis. Cardiac function was monitored during rest, mild exercise and isoproterenol infusion. Similar heart rates were maintained in both procedures. Peak pulmonary and aortic valve gradients as well as right and left ventr...

Sympathetic nervous system stimulation-induced β-adrenergic signal transduction is known to induce bone loss and increase of osteoclast activity. Although isoproterenol, a nonspecific β-adrenergic receptor agonist, has been shown to increase receptor activator of NF-κB ligand (RANKL), the details of the regulatory mechanisms remain unclear. In the present study, we investigated the role of the ...

BACKGROUND In susceptible humans, vasodepressor reactions are induced by restriction of venous return (upright tilting) and administration of isoproterenol. Because paradoxic bradycardia is a major manifestation of vasodepressor reactions, and allowing for extrapolation between paradoxic bradycardia in rats and vasodepressor reactions, we examined whether adenosine receptors mediate the paradox...

the internal mammary artery (ima) is currently the preferred conduit for myocardial revascularization. however, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. the mechanism of spasm has not been clearly defined. since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...

Sympathetic nervous activation is a crucial compensatory mechanism in heart failure. However, excess catecholamine may induce cardiac dysfunction and beta-adrenergic desensitization. Although magnesium is known to be a cardioprotective agent, its beneficial effects on acute cardiac dysfunction remain to be elucidated. We examined the effects of magnesium on left ventricular (LV) dysfunction ind...