نتایج جستجو برای: islet volumes
تعداد نتایج: 70205 فیلتر نتایج به سال:
27 Several mutant mouse models for human diseases such as diabetes mellitus have been 28 generated in the large-scale Munich ENU (N-ethyl-N-nitrosourea) mouse mutagenesis project. 29 The aim of this study was to identify the causal mutation of one of these strains and to 30 characterize the resulting diabetic phenotype. Mutants exhibit a T to G transversion mutation 31 at nt 629 in the glucokin...
BACKGROUND Oral vanadyl sulfate (vanadium) induces normoglycemia, proliferates beta cells and prevents pancreatic islet atrophy in streptozotocin-induced diabetic rats. Soteriological method is used to quantitate the proliferative effects of vanadium on beta-cell numbers and islet volumes of normal and diabetic rats. METHODS Adult male Sprague-Dawley rats were made diabetic with intravenous s...
Hyperinsulinism is responsible for about 55% of hypoglycemia in children less than 1 year old. In this study pancreas from 8 children with idiopathic hyperinsulinemic hypoglycemia of infancy(HHI) who underwent pancreatectomy in Ali-Asghar Hospital from 10 years ago were examined, using histochemical method and morphometric measurements. The children ranged from 3 to 13 months, and were ...
BACKGROUND Human allogeneic islet transplantation for treatment of type 1 diabetes provides numerous clinical benefits, such as fewer episodes of hypoglycemic unawareness and tighter control of blood glucose levels. Availability of human pancreas for clinical and research use, however, is severely limited. Porcine pancreas offers an abundant source of tissue for optimization of islet isolation ...
Background: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functi...
BACKGROUND Allogeneic human islet transplantation is an effective therapy for the treatment of patients with Type 1 Diabetes (T1D). The low number of islet transplants performed worldwide and the different transplantation protocols used limit the identification of the most effective therapeutic options to improve the efficacy of this approach. METHODS We present a retrospective analysis on th...
OBJECTIVE Curing type 1 diabetes by transplanting pancreatic islets into the liver is associated with poor long-term outcome and graft failure at least partly due to inadequate graft revascularization. The aim of the current study was to evaluate striated muscle as a potential angiogenic site for islet transplantation. RESEARCH DESIGN AND METHODS The current study presents a new experimental ...
abstract reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. it has been shown that progesterone and cilostazol possess antioxidant properties. the present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...
conclusions our results indicated that the dissemination of pi-1 was widespread in s. pneumoniae isolates, although no pi-2 isolates were detected. furthermore, the frequency of rlra and rrgc of clinical isolates was significantly more than that of normal flora isolates. results the results confirmed the presence of rlra and rrgc genes in both clinical (n = 39) and normal flora (n = 26) isolate...
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