نتایج جستجو برای: ischemiareperfusion ir injury
تعداد نتایج: 384577 فیلتر نتایج به سال:
Ischemia-reperfusion injury, a common complication during liver surgery where steatotic livers are more prone to the injury, may become more prevalent in the growing obese population. This study characterizes liver morphology toward understanding changes in subcellular function in steatotic livers exposed to ischemiareperfusion injury through quantitative description of fluorescein distribution...
OBJECTIVES Recent studies have revealed that nitric oxide (NO) in concert with lipid peroxidation (LP) may play an important role in pathophysiological mechanism(s) of cerebral ischemia. In addition, hyperglycemia exaggerates the pathological changes during cerebral ischemia. The purpose of this study was to investigate the effects of vitamin E (VE) on LP, NO production, and superoxide dismutas...
Purpose: To study the effect of dexmedetomidine (Dex) on myocardial ischemia-reperfusion injury (MIRI), and associated mechanism action.Methods: Sixty Sprague-Dawley (SD) rats were assigned to sham, (I/R), Dex, MD groups (methyllycaconitine prior injection with Dex), 15 in each group. Pathological changes tissues determined all groups. Protein expression levels HMGB1, TLR4, NF-κB myeloid differ...
SUDDEN CARDIAC ARREST IS THE most common lethal consequence of cardiovascular disease. Even if return of spontaneous circulation (ROSC) from cardiac arrest is achieved, approximately 60% of patients will not survive to hospital discharge. The high mortality is attributed to the postcardiac arrest syndrome, which involves global ischemiareperfusion injury, myocardial stunning, and anoxic brain i...
Introduction: Using brief episodes of ischemia and reperfusion (IR) prior to a more sustained IR insult – ischemic preconditioning (IPC) – can reduce IR injury of the heart, brain and many other tissues. The purpose of present study was to investigate the effect of 2min ischemic periods on subsequent rat renal IR injury. Methods: Male rat's renal IR injury was investigated in a right nephrectom...
SEE PAGE 47 A MP-activated protein kinase (AMPK) is a molecular energy sensor that is essential to the stress response in the heart (1). AMPK is activated during energy imbalance, when the ADPor AMP-toATP ratio increases. Because few proteins have adenine nucleotide binding domains, the activation of a protein kinase, which phosphorylates numerous downstream proteins, amplifies the energy stres...
Effect of sevoflurane delayed-postconditioning on ischemia-reperfusion injury in isolated rat hearts
Purpose: To evaluate the protective effect, effective time window, and mechanism of protection sevoflurane post-conditioning late on heart muscle ischemiareperfusion (I/R) lesion in isolated rat heart.Methods: Langendorff perfusion model was established Sprague-Dawley (SD) rats. After 15 min stabilization, rats were assigned to 10 groups, based treatments given: control group (TTC), I/R group, ...
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