erythropoietin. Transferrin saturation is a good indicator of the current balance of supply and demand of plasma iron, although it is an inadequate indicator of the amount of iron stored. In addition, Bainton and Finch showed that once the transferrin saturation falls below 16% iron supply for erythropoiesis may be inadequate.4 Our data also suggest that, during treatment with erythropoietin, m...

In this paper we present a method for determining the iron saturation of ferritin as a possible independent predictor of iron stores. Serum ferritin was purified by immunochemical precipitation, and could be completely recovered from serum without any contamination from transferrin. The iron content of the precipitated ferritin was determined by flameless atomic absorption spectrophotometry (FA...

We report our observations on day-to-day variation in serum ferritin, serum iron, total iron-binding capacity, and percent saturation of binding proteins with iron in 13 ostensibly healthy subjects during five weeks. The average intrasubject coefficients of variation were 14.5, 28.5, 4.8, and 28.0%, respectively. Precision studies on control samples showed greater within-assay and between-assay...

AIMS Excess iron has been implicated in the pathogenesis of diabetes and its complications. This study documents the assessment of plasma iron indices and the correlation between transferrin saturation with biochemical and clinical parameters in a cross-sectional survey of 820 patients with diabetes in long-term follow-up in a single clinic. METHODS Plasma iron indices, together with the bioc...

AIM To re-evaluate the diagnostic criteria of insulin resistance hepatic iron overload based on clinical, biochemical and histopathological findings. METHODS We studied 81 patients with hepatic iron overload not explained by known genetic and acquired causes. The metabolic syndrome (MS) was defined according to ATPIII criteria. Iron overload was assessed by liver biopsy. Liver histology was e...

introduction: hemodialysis patients often develop resistance to recombinant human erythropoietin due to functional iron deficiency. in these patients iron therapy can be hazardous leading to hemosiderosis. recent studies have suggested that intravenous ascorbic acid may be able to improve this hyporeponsiveness. the aim of this study was to evaluate the effect of intravenous ascorbic acid on fu...

Tests of iron and folate nutrition have been carried out in early pregnancy and at delivery in 63 Bantu females. Accepted normal values for serum iron, and percentage saturation of transferrin, but not for unsaturated iron-binding capacity, for non-pregnant subjects were found to apply equally well in pregnancy. Concomitant folate deficiency in early pregnancy did not render tests of iron defic...

Lactoferrin is considered as a part of the innate immune system that plays a crucial role in preventing bacterial growth, mostly via an iron sequestration mechanism. Recent data show that bovine lactoferrin prevents late-onset sepsis in preterm very low birth weight neonates by serving as an iron chelator for some bacterial strains; thus, it is very important to control the iron saturation leve...

dependent on iron delivery to developing erythrocytes; increased transferrin saturation may be essential to deliver iron when DMT1 activity is diminished. Thus, even if medications that increase hepcidin levels become available for treatment of iron overload, they may not benefit DMT1 patients because increased plasma hepcidin level would limit release of iron into the bloodstream, decreasing s...

Background: The prevalence of obesity is increasing and many countries are struggling with its high rate and serious complications. As a result of distinct diet in obese children, they may be susceptible to nutritional deficiencies in particular, iron deficiency. This study aimed to examine the relationship between obesity and iron indices. Methods: In this cross-sectional study, 206 element...