BACKGROUND Zoonotic cutaneous leishmaniasis (ZCL) is a polymorphic disease that may show various clinical manifestations. Although it is suggested that the genetic variability of the parasite is one of the factors influencing clinical manifestations of leishmaniasis, no data exists regarding genetic polymorphism of Leishmania major (L.major). This study investigates the determination of genetic...

The p53 tumor suppressor gene plays two important roles in genomic stability: blocking cell proliferation after DNA damage until it has been repaired, and starting apoptosis if the damage is too critical. Codon 72 exon4 polymorphism (Arg72Pro) of the P53 gene has been implicated in cancer risk. Various studies have been done to investigate the status of p53 at codon 72 for arginine (Arg) and pr...

obesity is currently considered as a serious global health problem which is influenced by environmental and genetic factors. association of genetic variants with obesity is widely scrutinized in recent years. the aim of this study was to evaluate present data on genetics of obesity in iranian population in a systematic review study. to obtain all related studies, google scholar, pubmed, and per...

conclusions: according to our results, it is likely that the increased frequency of the fcγriiib-na1/na2 genotype is associated with impaired immune responses against vl and its subsequent clearance from the patient. results: our results indicated that polymorphisms within the fcγriiib gene (that lead to the expression of the na1/na2 isoforms) are significantly associated with vl. the results d...

cardiovascular disease has become the main factor of death and birth defects in the world and also in iran. new clinical studies have shown that early diagnosis of patients with coronary artery disease (cad) can contribute to effective prevention or therapeutic structures, which reduce mortality or the next chance of cardiovascular events, and increase the quality of life. most studies on cad d...

angiotensin converting enzyme (ace; omim: 106180) has an important role in the conversion of angiotensin i to angiotensin ii and degradation of bradykinin. genetic polymorphism i/d (rs4646994) in the gene encoding ace has been well defined. to get more insight into the genetic structure of iranian populations, the distribution of the ace i/d polymorphism among iranians was compared with each ot...

There is several evidence suggests that thrombophilic gene polymorphisms may influence susceptibility to thromboembolic events. The prevalence of these polymorphisms is different in various races and ethnics. Accordingly, we studied the prevalence of Factor V (G1691A and A4070G), prothrombin G20210A and PAI-1 4G/5G in healthy northwest population of Iran. In this prospective study, 500 healthy ...

BACKGROUND Inflammatory bowel disease (IBD) is a chronic disease of unknown etiology, in which genetic factors, seem to play an important role in the disease predisposition and course. Assessment of tumor necrosis factor (TNF-α) gene polymorphisms in many populations showed a possible association with IBD. Considering the genetic variety in different ethnic groups, the aim of the present study ...

BACKGROUND Thermophilic campylobacters, particularly Campylobacter jejuni and C. coli are the main agents of human campylobacteriosis. Campylobacter contaminated chicken products is the most important source of foodborne gastroenteritis. Evaluation of genetic diversity among Campylobacter population is critical for understanding the epidemiology of this bacterium and developing effective contro...

the gene coding claudin (cldn5) is located on 22q11. since the proteins of cldn5 family are a ma-jor component for barrier-forming tight junctions, it may be important to test whether or not the cldn5 locus could be associated with schizophrenia.a total of 150 individuals affected with schizophrenia and 150 healthy persons were recruited. the relation-ship between the three single nucleotide po...