Shigella flexneri causes human dysentery after invading the cells of the colonic epithelium. The best-studied effectors of Shigella entry into colonocytes are the invasion plasmid antigens IpaC and IpaB. These proteins are exported via a type III secretion system (TTSS) to form a pore in the host membrane that may allow the translocation of other effectors into the host cytoplasm. TTSS-mediated...

Canadian Public AdministrationVolume 66, Issue 1 p. 149-149 ISSUE INFORMATION - IPACFree Access Information IPAC First published: 21 March 2023 https://doi.org/10.1111/capa.12476AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions of Use check box below share version article.I h...

BACKGROUND Recombinant vaccine technology is one of the most developed means in controlling infectious diseases. However, an effective vaccine against Shigella is still missing. OBJECTIVE To evaluate recombinant IpaC protein of Shigella as a vaccine candidate. METHODS In this study we cloned IpaC gene into an expression vector in prokaryotic system. The protein expression was evaluated by S...

Shigella flexneri contact with enterocytes induces a burst of protein secretion via its type III secretion apparatus (TTSA) as an initial step in cellular invasion. We have previously reported that IpaD is positioned at the TTSA needle tip (M. Espina et al., Infect. Immuno. 74:4391-4400, 2006). From this position, IpaD senses small molecules in the environment to control the presentation of Ipa...

Background: Recombinant vaccine technology is one of the most developed means in controlling infectious diseases. However, an effective vaccine against Shigella is still missing. Objective: To evaluate recombinant IpaC protein of Shigella as a vaccine candidate. Methods: In this study we cloned IpaC gene into an expression vector in prokaryotic system. The protein expression was evaluated by SD...

P.N. Appleton (IPAC), A.W. Blain (Caltech), C.M. Bradford (JPL), C.R. Bridge (SSC), R. Chary (SSC), E. Daddi (CEA Saclay), V. Desai (SSC), M. Harwit (Cornell), G. Helou (IPAC), P.F. Hopkins (UC Berkeley), M. Malkan (UCLA), J. Melbourne (Caltech), E.J. Murphy (SSC), P. Ogle (SSC), C. Papovich (Texas A&M), A. Pope (NOAO), D. Riechers (Caltech), J.R. Rigby (OCIW), J.D. Smith (Toledo), G. Stacey (C...

Real-time and embedded systems have traditionally been designed for closed environments where operating conditions, input workloads, and resource availability are known a priori and are subject to little or no change at runtime. There is an increasing demand, however, for autonomous capabilities in open distributed real-time and embedded (DRE) systems that execute in environments where input wo...

BACKGROUND Environmental contamination in hospitals with antibiotic-resistant organisms (AROs) is associated with patient contraction of AROs. This study examined the working relationship of Infection Prevention and Control (IPAC) and Environmental Services and the impact of that relationship on ARO rates. METHODS Lead infection control professionals completed an online survey that assessed t...

P. N. Appleton SIRTF Science Center, MS 220-6, California Institute of Technology, Pasadena CA 91125 V. Charmandaris Astronomy Department, Cornell University, 106 Space Sciences Bldg, Ithaca NY 14853 Yu Gao IPAC, MS 100-22, Infrared Processing & Analysis Center, Caltech, Pasadena CA 91125 & Department of Astronomy, University of Massachusetts, LGRT-B 619E, 710 North Pleasant Street,Amherst, MA ...