نتایج جستجو برای: ip and rs
تعداد نتایج: 16837129 فیلتر نتایج به سال:
منطقه اکتشافی بوته گز در استان خراسان رضوی، در 34 کیلومتری شمال تربت جام قرار دارد. زمین شناسی این منطقه شامل توده های دیوریتی، گرانودیوریتی و سینوگرانیتی است که در سنگ های دگرگونی شده سازند میان کوهی به سن تریاس نفوذ کرده اند. پذیرفتاری مغناطیسی توده های منطقه کمتر ازsi 5-10×5 بوده و از نوع سری ایلمنیت (احیایی) می باشند. این توده ها متاآلومینوس تا پرآلومینوس بوده و از کالک آلکالن با پتاسیم م...
منطقهی پیجویی بوتهگز استان خراسانرضوی در 34 کیلومتری شمال تربتجام قرار دارد. زمینشناسی این منطقه شامل تودههای دیوریتی، گرانودیوریتی و سینوگرانیتی است که در سنگهای دگرگون نفوذ کردهاند. پذیرفتاری مغناطیسی تودههای منطقه کمتر ازsi 5-10×5 بوده و از نوع سری ایلمنیت (احیایی) هستند. این تودهها شبه رخشان تا پرآلومینوس بوده و از پتاسیم آهکی قلیایی میانگین تا سری شوشونیتی متغیرند. 4 نوع دگرس...
Store-operated Ca(2+) channels (SOCs) mediate receptor-stimulated Ca(2+) influx. Accumulating evidence indicates that members of the transient receptor potential (TRP) channel family are components of SOCs in mammalian cells. Agonist stimulation activates SOCs and TRP channels directly and by inducing translocation of channels in intracellular vesicles to the plasma membrane (PM). The mechanism...
The aims of the present study were to examine the relationship between serum B-cell activating factor belonging to the tumor necrosis factor family (BAFF) levels and serum interferon-γ-inducible protein-10 (IP-10) levels in patients with autoimmune hepatitis (AIH).A total of 80 corticosteroid therapy naive AIH patients were analyzed in this analysis. First, we examined the relationship between ...
Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) mediate cytosolic free calcium concentration ([Ca(2+)](c)) signals in response to a variety of agonists that stimulate mesangial cell contraction and proliferation. In the present study, we demonstrate that mesangial cells express both type I and III IP(3)Rs and that these receptors occupy different cellular locations. Chronic treatment with tran...
We explored a potential structural and functional link between filamentous actin (F-actin) and inositol (1,4,5)-trisphosphate receptors (IP(3)Rs) in mouse pancreatic acinar cells. Using immunocytochemistry, F-actin and type 2 and 3 IP(3)Rs (IP(3)R2 and IP(3)R3) were identified in a cellular compartment immediately beneath the apical plasma membrane. In an effort to demonstrate that IP(3)R distr...
Calcium (Ca(2+)) release through inositol 1,4,5-trisphosphate receptors (IP(3)Rs) regulates the function of virtually every mammalian cell. Unlike ryanodine receptors, which generate local Ca(2+) events ("sparks") that transmit signals to the juxtaposed cell membrane, a similar functional architecture has not been reported for IP(3)Rs. Here, we have identified spatially fixed, local Ca(2+) rele...
The liberation of calcium ions sequestered in the endoplasmic reticulum through inositol 1,4,5-trisphosphate receptors/channels (IP(3)Rs) results in a spatiotemporal hierarchy of calcium signaling events that range from single-channel openings to local Ca(2+) puffs believed to arise from several to tens of clustered IP(3)Rs to global calcium waves. Using high-resolution confocal linescan imagin...
Distribution and functional role of inositol 1,4,5-trisphosphate receptors in mouse sinoatrial node.
RATIONALE Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) have been implicated in the generation of arrhythmias and cardiac muscle nuclear signaling. However, in the mammalian sinoatrial node (SAN), where the heart beat originates, the expression and functional activity of IP(3)Rs have not been investigated. OBJECTIVES To determine whether SAN express IP(3)Rs and which isoforms are present. ...
Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) are large, ubiquitously expressed, endoplasmic reticulum membrane proteins that form tetrameric IP(3) and Ca(2+)-gated Ca(2+) channels. Endogenous IP(3)Rs provide very appealing tools for studying the ubiquitin-proteasome pathway in intact mammalian cells because, upon activation, they are rapidly ubiquitinated and degraded. Using mass sp...
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