The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis. Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/v solution of lidocaine hydrochloride. Tape stripping was done to quantify the...

This systematic review and meta-analysis is focusing on the evidences related to iontophoresis used to enhancethe topical drug delivery through the skin in the treatment of inflammatory dysfunctions, acute soft tissue injuries andpain. A literature search in the databases, MEDLINE (PubMed), Pedro, and the Cochrane Database of Systematic Re-views was conducted. The methodological qua...

PREFACE Iontophoresis is a process which involves increased transport of solute molecules into a tissue using an electric current. This technique has been employed for the delivery of ionic drugs for local and systemic therapeutic effects in clinical settings. Iontophoresis is becoming more widespread today with many pharmacists compounding solutions for this mode of administration. Iontophores...

PREFACE Iontophoresis is a process which involves increased transport of solute molecules into a tissue using an electric current. This technique has been employed for the delivery of ionic drugs for local and systemic therapeutic effects in clinical settings. Iontophoresis is becoming more widespread today with many pharmacists compounding solutions for this mode of administration. Iontophores...

The aim of the present study was to develop and investigate the feasibility of delivering Nebivolol as a transdermal patch by iontophoresis. The passive and electrically assisted transdermal delivery of Nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. Because of its extensive hepatic metabolism and low dos...

BACKGROUND AND PURPOSE Iontophoresis is a process that uses bipolar electric fields to propel molecules across intact skin and into underlying tissue. The purpose of this study was to describe and experimentally examine an iontophoresis drug delivery model. SUBJECTS AND METHODS A mechanistic model describing delivery was studied in vitro using agarose gels and was further tested in vivo by ev...

Iontophoresis is a strategy to increase the penetration of drugs through biological membranes; however, its use has been underexplored in mucosa. The aim of this work was to investigate the influence of iontophoresis in the mucosal penetration of prilocaine hydrochloride (PCL) and lidocaine hydrochloride (LCL), which are largely used in dentistry as local anesthetics, when combined in the same ...

PURPOSE To indirectly measure stromal riboflavin penetration using commercially available riboflavin solutions and new and existing epithelium-off, trans-epithelial and iontophoresis-assisted delivery protocols. METHODS Forty porcine eyes were divided into eight groups. Group 1: Ricrolin applied to the de-epithelialised cornea for 30 min; Group 2: epithelium-intact, no treatment; Groups 3-5: ...