To the Editor: Iohexol is regarded as an accurate filtration marker for measuring GFR. Recently, Soveri et al concluded that plasma clearance of iohexol could be considered a valid alternative to the gold standard, urinary clearance of inulin. Because inulin urinary clearance is cumbersome and costly, iohexol and iothalamate clearance have become popular in Europe and the United States, respect...

BACKGROUND AND PURPOSE Contrast-induced acute kidney injury (CI-AKI) is a serious complication of the use of iodinated contrast agents. This problem is particularly acute in interventional neurology and interventional cardiology, probably due to the intra-arterial route of injection, high contrast volumes, and preexisting risk factors of these patients. In an attempt to develop a contrast agent...

BACKGROUND Barium sulfate powder used for radiopacity of experimental blood clots (EBCs) for testing mechanical thrombectomy devices (MTD) has negative effects on EBCs mechanical properties. In vitro and in vivo exploration was performed to determine if the iodine based contrast medium will have less negative effects on the EBCs than barium. MATERIALS AND METHODS Fresh blood from 2 swine was ...

1 The renal handling of iohexol was examined in the rat isolated perfused kidney (IPK)-1 (C1r/GF) of 0.63 ± 0.06 could be indicating that a saturable mechanism is involved in the luminal disappearance of the drug. 3 Pretreatment of the kidneys with polylysine, probenecid or diatrizoate resulted in a significantly enhanced clearance o f iohexol, probably due to inhibition of membrane binding. Re...

To prepare lomustine-iohexol thermosensetive compound liposomes, and evaluate the properties and in vitro release behaviors of two drugs enveloped. Lomustine-iohexol thermosensetive compound liposomes were prepared by reverse evaporation method, HPLC assays for determination of lomustine and iohexol in vitro were developed, and their release property was studied by using dislysis method. The me...

BACKGROUND The aim was to evaluate the reproducibility of glomerular filtration rate (GFR) measured with iohexol and its response to food in a direct and independent comparison with Cr-51-ethylenediaminetetraacetic acid (EDTA), and examine the influence of two different whole body scaling parameters, body surface area (BSA) and extracellular fluid volume (ECV). METHODS Fasting and non-fasting...

BACKGROUND The aim of this study was to compare the safety and intra-individual contrast enhancement of low-osmolar monomeric iohexol and the iso-osmolar dimeric iodixanol in body computed tomography (CT) scanning. METHODS In this single center, double-blind, prospective study, a total of 2000 consecutive patients undergoing adult body CT scanning were prospectively enrolled, with 1000 patien...

conclusions compared to iohexol and iopamidol, iodixanol use was associated with a lower patient perception of heat and lower hr while maintaining similar contrast-to-noise and signal-to-noise ratios. results baseline hr was similar across the patients assigned to iohexol, iopamidol, and iodixanol (65.3 ± 9.7, 66.9 ± 10.9, and 65.3 ± 13.3, respectively; p = ns). compared to iohexol and iopamido...

Iodixanol, a new ratio 6 nonionic iodinated contrast agent with an osmolality equal to serum, was compared with iohexol in a randomized, double-blind, parallel study. Two hundred patients undergoing elective diagnostic cardiac angiography were randomized to iodixanol (n = 101) or iohexol (n = 99). There were no differences noted between the 2 agents in the mean changes in systolic or diastolic ...

OBJECTIVE-To evaluate use of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) to estimate glomerular filtration rate (GFR) by plasma clearance and use of an ELISA as the method of Gd-DTPA quantification. ANIMALS-16 dogs of various sexes and breeds (12 dogs were clinically normal, and 4 dogs were polyuric and polydipsic with no other clinical or biochemical abnormalities). PROCEDURES-GFR...