Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε-aminotransferase, chorismate mutase, and pantothenate synthetase. The enzymes are related to the nongrowing state of Mycobacterium tuberculosis. Salicyla...

a facile one step synthesis of anilino alky1-n-substituted phthalimide i is reported. the following compounds belonging to this series were made: 1. (anilino-n-ethyl) phthalimide 8 2. (3,4, 5-trimethoxy anilino-n-ethyl) phthalimide 6 3. (3,4, 5-trimethoxy anilino-n-propyl) phthalimide 7 4. n-(ethyl phthalirnido-p-amino benzoyl) glutamic acid diethyl ester 10 5. n-(propyl phthalimido-p-amino ben...

background: the present study was undertaken to study the larvicidal activity of different extracts of nerium ole- ander leaves, and post-treatment temperature- toxicity relationship of these extracts against culex pipiens. further, the most potent extract was used to evaluate its biological and genotoxic activities. methods: crude extracts of n. oleander leaves were prepared using water, chlor...

Sponges, which constitute the phylum Porifera, are the most primitive of the multicellular animals, among all marine organisms screened. Marine sponges produce the largest number of structurally diversified natural products. In this study we investigated in vitro antimicrobial activity of Ircinia mutans collected from the Kish Island in the Persian Gulf against strains of bacteria Escherichia c...

A study was undertaken in order to understand the kinetics and mechanism of the chemical oxidation of N,N-diethyl-m-toluamide, an insect repellent, by sulfate radical. In this experiment, sulfate radical was generated using peroxymonosulfate with iron(II) and cobalt(II) as activator. The second-order rate constant for the reaction of the sulfate radical with N,N-diethyl-m-toluamide was found to...

background: this study aimed at determining the appropriate method for dewatering and drying biomass and selecting a suitable organic solvent for lipid extraction. methods: nannochloropsis oculata was cultured in gillard f/2 medium and after reaching the end of the stationary growth phase, algal biomass was separated from aqueous by centrifuge and dried through three methods: oven, air-dried an...

Diethyl phthalate works as a phthalate plasticizer and is ubiquitously used in personal care products, cosmetics, medical equipment and pharmaceutical coating. Diethyl phthalate is considered a potential endocrine disruptor. Previously we found diethyl phthalate enhanced apoptosis induced by serum deprivation in PC12 cells. However, the relationship between diethyl phthalate and longevity relat...

A novel class of aryl vinyl ethers 3 and diethyl 3-cyano-3-alkylprop-1-en-2-ylphosphonates 4 has been prepared, respectively, from coupling reaction of diethyl 1-(bromomethyl)-2-cyanovinylphosphonate 2 with phenols and Gilman reagents.

The pH rate profile for the hydrolysis of diethyl-p-nitrophenyl phosphate catalyzed by the phosphotriesterase from Pseudomonas diminuta shows a requirement for the deprotonation of an ionizable group for full catalytic activity. This functional group has an apparent pKa of 6.1 +/- 0.1 at 25 degrees C, delta Hion of 7.9 kcal/mol, and delta Sion of -1.4 cal/K.mol. The enzyme is not inactivated in...