The hierarchical iodine( i ) species [bis(3-acetaminopyridine)iodine( )]PF 6 possesses two temperature-dependent solid-state connectivities of the hydrogen bonding and demonstrates unprecedented iodination reactivity toward t BuOMe.

A mild and rapid method for the iodination of arenes that utilizes silver(I) triflimide as a catalyst for activation of N-iodosuccinimide has been developed. The transformation was found to be general for a wide range of anisole, aniline, acetanilide, and phenol derivatives and allowed the late-stage iodination of biologically active compounds such as PIMBA, a SPECT imaging agent of breast canc...

A protocol for the C−H activation/iodination of benzoic acids catalyzed by a simple iridium complex has been developed. The method described in this paper allows the orthoselective iodination of a variety of benzoic acids under extraordinarily mild conditions in the absence of any additive or base in 1,1,1,3,3,3-hexafluoroisopropanol as the solvent. The iridium catalyst used tolerates air and m...

Lead interferes with heme synthesis in erythrocytes and has a deleterious effect on red cell membranes. We measured myeloperoxidase (MPO) enzyme activity in the granulocytes of dogs fed increasing quantities of lead. Concurrently, iodination capability and in vitro bactericidal activity were measured. Blood lead levels were monitored. Three of 4 dogs poisoned with lead developed significant dec...

ABSTRACT. Iodinated heterocyclic molecules are crucial structural components of many natural products, including hormones, vitamins, and medicines. The pharmaceutical survey is very interested in the investigation kinetics iodination N-(p-chlorophenyl)-3,5-dimethyl-1,1-dioxo-1,2-thiazine. rate directly dependent on concentration both 1,2-thiazine iodine under different molar ratios (1:10), (10:...

1. The effect of iodination on the distribution of peptide hormones into the aqueous two-phase dextran-polyethylene glycol system and on the solubility of these hormones in aqueous polyethylene glycol and in water was assessed. Hormones that were studied included insulin, glucagon and parathyroid hormone. 2. The partition coefficient of native insulin in the dextran-polyethylene glycol system s...

The site of iodination of thyroglobulin in the thyroid gland revealed through morphological studies was critically reviewed in relationship to biochemical points of view. The phylogenetic and evolutional aspects of this problem were also reviewed and discussed. To conclude, the present author wishes to emphasize the following: 1. In adult vertebrates whose thyroid follicular structure has been ...

Insulin receptors from human placenta have been labeled by using an oxidative iodination procedure (iodogen-mediated or chloramine-T-mediated), Bolton-Hunter reagent or [3H]acetic anhydride. The oxidative iodination procedure reduces the affinity for 131I-insulin and the receptor protein becomes fragmented into smaller pieces with an s20,w value of 5-6. However, treatment with Bolton-Hunter rea...

Five different quorum sensing peptides (QSP) were iodinated using different iodination techniques. These iodinated peptides were analyzed using a C18 reversed phase HPLC system, applying a linear gradient of water and acetonitrile containing 0.1% (m/v) formic acid as mobile phase. Electrospray ionization (ESI) ion trap mass spectrometry was used for the identification of the modified peptides, ...

Thyroglobulin has been iodinated at pH 9.35 and the distribution of iodoamino acids has been determined. Iodination results in a decrease in the tyrcsyl and an increase in the diiodotyrosyl difference spectra peaks. The spectral changes indicate that tyrosyl groups, which are more or less shielded from the solvent, can also react with iodine. Based on recent model studies on the rates of iodina...