Background & Aims: This study was performed to investigate possible relationships between the manifestation of stromal cells (fibroblasts and/or myofibroblasts) by focusing on expression of their matrix metalloproteinase 9 (MMP9) and possible angiogenesis based on CD31 and CD34 antigen expression during the various steps of hyperplastic changes to precancerousstate and invasive breast cancer. M...

pure apocrine carcinoma of the breast is one of the rare variants of invasive breast carcinoma. significant research has been conducted on cases of apocrine carcinoma, and the results may help in development of new therapies and assessing prognosis. we hereby present a case of pure invasive apocrine carcinoma in a 50-year old female, with a short review of recent developments with regard to thi...

The focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. For this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (DCIS), was evaluated by immunohistochemical method. All specimens were microscopically classified into histologic types...

background and objectives: breast cancer is the most common malignancy in women throughout the world. there are controversial reports on the role of human papillomavirus (hpv) infection in breast carcinogenesis. the aim of this study was to assess the presence of hpv-dna in invasive breast carcinoma to determine the association between hpv infection and breast carcinoma. methods: the study incl...

Granular cell tumor is a rare benign non-encapsulated tumor that mostly presents in oral cavity. Breast localization is uncommon and occurs in about one per 1000 cases of breast cancers. It mainly affects premenopausal women showing the possible role of estrogen and progesterone levels in the progression of this tumor. Granular cell tumor is a great emulator of the invasive ductal carcinoma of ...

background: mammary paget’s disease is an uncommon form of primary breast cancer. the aim of this study is to assess our institution’s experience in its management. methods: we retrospectively reviewed the medical records of 53 female patients with histologically confirmed paget’s disease, treated at the salah azaïz institute between 2001 and 2010. results: there were palpable masses in 71.7% o...

During the investigation of the fate of estrone in blood and perfused organs, it was found that@ estrone was converted to a biologically inactive substance (1) , which could no longer be assayed as a 17-ketosteroid (i). Utilization of this latter fact in a study of the conditions under which this con version could occur provided evidence supporting the hypothesis that an enzyme catalyzing the r...

background conservative surgical treatment has been the treatment of choice for early breast cancer. it allows feasible oncological treatment with a satisfactory cosmetic approach and fast recovery. however, in some cases mastectomy is necessary. this study proposes a surgical approach with only one surgical access through the same incision, which is in line with precepts mentioned above. it is...