Invasive aspergillosis (IA) is a serious opportunistic infection, which has increasingly been recognized as an emerging disease of non-neutropenic patients. In this group of patients, the diagnosis of IA can be challenging owing to the lack of specificity of symptoms, the difficulty in discriminating colonization from infection, and the lower sensitivity of microbiological and radiological test...

The frequency of use of systemic antifungal agents has increased significantly in most tertiary centers. However, antifungal stewardship has received very little attention. The objective of this article was to assess the knowledge of prescribing physicians in our institution as a first step in the development of an antifungal stewardship program. Attending physicians from the departments that p...

comments on ''detection of galactomannan in the bronchoalveolar lavage of high-risk patients with invasive aspergillosis admitted at the intensive care unit'' by khodavaisy et al.  awt-sep    awt-sep    awt-sep    awt-sep    awt-sep    awt-sep  galactomannan in bronchoalveolar lavage for diagnosis of invasive aspergillosis  we read with interest the prospective study by khod...

Aspergillus infections are a threat to in patients with hematological malignancies. Known risk factors are profound and long lasting neutropenia, uncontrolled graft versus host disease, continuous administration of steroids and environmental factors such as hospital construction. Numerous efforts have been undertaken for prophylaxis of invasive aspergillosis in high-risk populations. Most of th...

Invasive tracheobronchial aspergillosis that is entirely limited or predominantly confined to tracheobronchial lesions is a relatively rare form of invasive pulmonary aspergillosis. Extended parenchymal opacities that are radiological manifestations of invasive aspergillosis sometimes occur following invasive tracheobronchial aspergillosis. However, it remains unclear whether or not invasive tr...

AIMS To evaluate the Pastorex aspergillus antigen latex agglutination test for the diagnosis of invasive aspergillosis in patients undergoing liver or bone marrow transplantation. METHODS Serum samples were taken at least twice weekly post-transplant and tested for Aspergillus antigen. Latex agglutination test results were compared with microbiological examination of respiratory, urine and bi...

Purpose: The aim of this study was to review the epidemiology, clinical features, diagnosis, and effect of treatments of aspergillosis infections in adult liver transplantation patients. Methods: We retrospectively studied the cases of aspergillosis among 625 (164 deceased donor liver transplantation (DDLT), 461 living donor liver transplantation (LDLT)) adult liver transplantation recipients (...

background and purpose: invasive aspergillosis (ia) is one of the most common life-threatening fungal infections among the critically ill patients including intensive care unit (icu) patients. delayed diagnosis and therapy may lead to poor outcomes. diagnosis may be facilitated by a test for molecular biomarkers, i.e. detection of galactomannan (gm) antigen based on enzyme immunoassay, which is...

invasive aspergillosis (ia) are a major complication in immunocompromized patients where can be serious and rapidly fatal. early diagnosis and early appropriate antifungal treatment is important in reducing mortality and morbidity. but despite many efforts to develop detection methods, the diagnosis of ia still remains challenging and current conventional methods are limited for adequate diagno...