To date, preterm infants with respiratory distress syndrome (RDS) after birth have been managed with a combination of endotracheal intubation, surfactant instillation, and mechanical ventilation. It is now recognized that noninvasive ventilation (NIV) such as nasal continuous positive airway pressure (CPAP) in preterm infants is a reasonable alternative to elective intubation after birth. Recen...

Objective : To identify which factors can predict INSURE failure in preterm infants with respiratory distress syndrome. Study design : A retropective analysis of the prenatal histories, clinical courses and paraclinical data of all inborn infants (birth weight < 2000g) with respiratory distress syndrome treated with INSURE method. Infants were categorized into 2 groups : "INSURE failure group" ...

background: in recent years, various noninvasive respiratory support (nrs) of ventilation has been provided more in neonates. the aim of this study was to compare the effect of hfnc with ncpap in post-extubation of preterm infants with rds after insure method (intubation, surfactant, extubation). methods: a total of 54 preterm infants with rds (respiratory distress syndrome) were enrolled in th...

BACKGROUND Various strategies have been suggested for the treatment of respiratory distress syndrome (RDS). OBJECTIVES The aim of this study was to compare the efficacies of two common methods of RDS management among neonates with low birth weight. PATIENTS AND METHODS A cohort study was conducted on 98 neonates with definite diagnosis of RDS during 2008-2009. The neonates were divided into...

Background: In recent years, various noninvasive respiratory support (NRS) of ventilation has been provided more in neonates. The aim of this study was to compare the effect of HFNC with NCPAP in post-extubation of preterm infants with RDS after INSURE method (intubation, surfactant, extubation).Methods: A total of 54 preterm infants with RDS (respiratory distress syndrome) were enrolled in thi...

OBJECTIVE To determine whether very low birth weight infants (VLBWIs), initially supported with continuous positive airway pressure (CPAP) and then selectively treated with the INSURE (intubation, surfactant, and extubation to CPAP; CPAP/INSURE) protocol, need less mechanical ventilation than those supported with supplemental oxygen, surfactant, and mechanical ventilation if required (Oxygen/me...

Administration of endotracheal surfactant is potentially the main treatment for neonates suffering from RDS (Respiratory Distress Syndrome), which is followed by mechanical ventilation. Late and severe complications may develop as a consequence of using mechanical ventilation. In this study, conventional methods for treatment of RDS are compared with surfactant administration, use of mechanical...

Background Intubation-Surfactant-Extubation (InSurE) and less invasive surfactant administration (LISA) are alternative replacement therapy methods for reducing the complications associated with mechanical ventilation. This study aimed to compare Classic, InSurE, LISA in Very-Low-Birth-Weight infants (VLBWIs) South Korea. Methods The Korean Neonatal Network (KNN) enrolled VLBWIs born between Ja...

Survival and outcomes for preterm infants with respiratory distress syndrome (RDS) have improved over the past 30 years. We conducted a study to assess the changes in perinatal care and delivery room management and their impact on respiratory outcome of very low birth weight newborns, over the last 15 years. A comparison between two epochs was performed, the periods before and after 2005, when ...

BACKGROUND In addition to surfactant deficiency, increase of lung fluid content and secretion of fluid derived from the blood participate in the pathogenesis of RDS in newborns. We hypothesized that the administration of salbutamol (β-agonist) to increase lung fluid absorption would decrease the INSURE failure rate in newborns with respiratory distress syndrome (RDS) treated with intratracheal ...