as a supplement to the oral method has been pointed out by many workers. Moreover, the possibility of error in the result of oral method due to diminished absorption has been shown by Beeler, Bryan, Cathcart and Fitz (1922). The flat blood sugar curve obtained by Thaysen (1929) after the oral administration of glucose, as has been shown by the author, is due to the diminished absorption of gluc...

Chronic sleep curtailment in humans has been related to impairment of glucose metabolism. To better understand the underlying mechanisms, the purpose of the present study was to investigate the effect of acute sleep deprivation on glucose tolerance in rats. A group of rats was challenged by 4-h sleep deprivation in the early rest period, leading to prolonged (16 h) wakefulness. Another group of...

OBJECTIVE Impaired glucose effectiveness (GE) plays a role in the deterioration of glucose metabolism. Our aim was to validate a surrogate of GE derived from an oral glucose tolerance test (OGTT) and to assess the impact of degrees of obesity and of glucose tolerance on it. RESEARCH DESIGN AND METHODS The OGTT-derived surrogate of GE (oGE) was validated in obese adolescents who underwent an O...

Diabetes affects millions of Americans, and the correct identification of individuals afflicted with this disease, especially of those in early stages or in progression towards diabetes, remains an active area of research. The minimal model is a simplified mathematical construct for understanding glucose-insulin interactions. Developed by Bergman, Cobelli, and colleagues over three decades ago,...

1. Modelling analysis of intravenous glucose tolerance test glucose and insulin concentrations can provide measures of insulin sensitivity and metabolism from a single straightforward procedure. However, little is known of the effects of blood arterialization on model-derived parameters. 2. Intravenous glucose tolerance tests were carried out on 18 subjects, with measurement of glucose and insu...

The purpose of this study was to determine the normal range and test variability for intravenous glucose tolerance test (IVGTT) in rabbits. Fifty one clinically healthy New Zealand white rabbits of both sexes (31 female and 20 male), 3.5−4 months of age and weighing 2.8 to 3.7 kg were used. The IVGTT was performed after an overnight fasting period of 12 h by intravenous injection of 40% glucose...

1. Danazol elevates plasma insulin, plasma glucagon and serum low-density lipoprotein concentrations and reduces the serum high-density lipoprotein concentration. 2. Associations between these disturbances were studied in 17 women receiving danazol therapy for endometriosis. Eleven women underwent intravenous glucose tolerance tests with measurement of plasma glucose, insulin, C-peptide and glu...