Ocular immune privilege (IP) limits the immune surveillance of intraocular tumors as certain immunogenic tumor cell lines (P815, E.G7-OVA) that are rejected when transplanted in the skin grow progressively when placed in the anterior chamber of the eye. As splenectomy (SPLNX) is known to terminate ocular IP, we characterized the immune mechanisms responsible for rejection of intraocular tumors ...

Human intraocular tumors and tumors derived from human tumor cell lines grown subcutaneously in the athymic nude mouse were scanned by diagnostic ultrasound. Radiofrequency scan data were converted to digital form and analyzed in the frequency domain. Characteristics of normalized power spectra were found to be significantly different among human spindle cell malignant melanomas, mixed/epitheli...

Although intraocular tumors reside in an immune privileged site, some tumors are rejected nonetheless. For example, intraocular adenovirus-induced (Ad5E1; adenovirus type 5 early region 1) tumors are rejected in syngeneic C57BL/6 mice by one of two pathways. One pathway leads to extensive necrosis of innocent bystander cells and culminates in destruction of the eye, a condition called phthisis....

Although intraocular tumors reside in an immune privileged site, some tumors are rejected nonetheless. For example, intraocular adenovirus-induced (Ad5E1; adenovirus type 5 early region 1) tumors are rejected in syngeneic C57BL/6 mice by one of two pathways. One pathway leads to extensive necrosis of innocent bystander cells and culminates in destruction of the eye, a condition called phthisis....

retinoblastoma is the most common intraocular neoplasm in children. glial tumor of the retina and optic nerve head are considered to be congenital and are therefore classified as hamartomas. concurrent occurrence of these tumors in one eye is uncommon and by reviewing the studies, a few cases have been reported. we report a 9 years old boy with eye enucleation and concurrent occurrence of retin...

Intraocular tumors of any type are uncommon. The most common primary malignant tumor of the eye, uveal melanoma, occurs in 7 persons per million population per year -less than one tenth the incidence of lung cancer. Retinoblastoma occurs as a childhood disease approximately as frequently as hemophilia. These two intraocular tumors, related only by anatomic proximity, have very different histories.