abscess formation following intramuscular injections is rare and they are most commonly seen in immunocompromised individuals. in this case series we present a cohort of three patients presented to us in a critically ill condition with an abscess due to intramuscular injection. vancomycin resistant staphylococcus aureus was isolated from all three patients. these patients posed a major challeng...

BACKGROUND The utility of intramuscular (IM) oxytocin for the prevention of postpartum hemorrhage in resource-poor settings is limited by the requirement for temperature-controlled storage and skilled staff to administer the injection. We evaluated the safety, tolerability and pharmacokinetics (PK) of a heat-stable, inhaled (IH) oxytocin formulation. METHODS This phase 1, randomized, single-c...

pain in neonates can be associated with various risks and it seems essential to find a simple and acceptable method for relieving pain. pharmacologic agents are not recommended in neonates for pain relief in minor procedures but orally administered glucose solution is found to be effective. the objective of this study was to assess the efficacy of oral 30% glucose during intramuscular injection...

background: dna immunization with plasmid dna encoding bacterial, viral, parasitic, and tumor antigens has been reported to trigger protective immunity. the use of plasmid dna vaccinations against many diseases has produced promising results in animal and human clinical trials; however, safety concerns about the use of dna vaccines exist, such as the possibility of integration into the host gen...

OBJECTIVES To compare oral misoprostol versus intramuscular oxytocin in the management of third stage of labour. METHODS The quasi-experimental study was conducted at the Obstetrics and Gynaecology Unit II, Civil Hospital, Karachi, from June 20 to December 19, 2006. A total of 70 patients diagnosed in active phase of labour who fulfilled the inclusion criteria were selected by non-probability...

Introduction: Oxytocin is a active neuropeptide of central nervous system. In this study the effects of naloxone (opioid receptor antagonist) and yohimbine (α-2 adrenergic receptor antagonist) on analgesic effect of oxytocin applied into the locus coeruleus (LC) nucleus were investigated. Methods: Adult male Wistar rats were used. Animals divided into different groups receiving saline, oxy...

Objective: To compare the efficacy of Oxytocin versus Methylergometrine in active management of third stage of labour in reducing risk of postpartum hemorrhage. Methods: This study was carried out by randomly assigning into two groups with 150 women in each group. Group 1 included patients who received injection Oxytocin 10 IU intramuscular within one minute of the birth of the baby. Injection ...

OBJECTIVES To compare oxytocin plus ergometrine against oxytocin alone, when administered as part of the active management of the 3rd stage of labor, in terms of postpartum hemorrhage and manual removal of the placenta. DESIGN A double-blind, randomized controlled trial. SETTING A university teaching hospital: Hope Hospital, Salford. PATIENTS All women delivering in the hospital over the ...