The disposition kinetics and dosage regimen of cefepime were compared after its intravenous and intramuscular administration at 10 mg.kg-1 in healthy buffalo calves. The drug concentration in plasma was estimated by microbiological assay. The peak plasma concentration of cefepime after intravenous injection was at 1 min (46.4 ± 0.40 g.ml-1) and after intramuscular administration it was at afte...

the pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above mic90  in plasma was detected up to 12 h of administration. the bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1....

pharmacokinetics of ceftriaxone was studied in buffalo calves (bubalus bubalis) after single intravenousand intramuscular administration of 10 mg/kg body weight. the drug concentrations in plasma samples weremeasured by high performance liquid chromatography with uv detection. following intravenousadministration, the drug was rapidly distributed (cpo: 106.5 ± 9.64 μg/ml; t1/2α: 0.09 ± 0.01 h; v...

Midazolam is a water soluble 1,4 benzodiazepine which is suitable for intramuscular administration. It is currently used for pre-medication and the induction of anaesthesia. Its antiepileptic properties have been evaluated by studying its effect on interictal spikes on the EEG of six adult epileptic patients. The results indicate that intramuscular midazolam 15 mg is more effective than intramu...

OBJECTIVES To investigate whether childhood cancer is associated with intramuscular administration of vitamin K to newborn infants. DESIGN Routines for administration of vitamin K to infants born after normal deliveries during 1973-89 were obtained from maternity hospitals. Occurrence of cancer up to the end of 1991 was identified by comparing these records with the national cancer registry. ...

The pharmacokinetics of isepamicin following administration of a 1-g dose were evaluated for 18 healthy male volunteers between the ages of 26 and 38. In a randomized crossover fashion, each volunteer received doses of isepamicin by a 30-min intravenous infusion and as an intramuscular injection. Blood samples were collected at specified times after dosing and assayed for isepamicin by a valida...

Pharmacokinetics and residue elimination of streptomycin sulfate (STR) are important in the determination of optimal dosage regimens and in establishing safe withdrawal periods in farmed fishes. The pharmacokinetics of STR was studied after a single dose (50 mg/kg) of intramuscular (i.m.) or oral gavage (p.o.) administration to Japanese eel (Anguilla japonica) in freshwater at 25 ̊C. Eight fish ...