TrkA, the nerve growth factor (NGF) tyrosine kinase receptor, is expressed not only in the nervous system, but also in nonneural cells, including discrete cellular subsets of the endocrine and immune system. In the rat ovary, trkA receptor abundance increases strikingly in thecal-interstitial cells during the hours preceding the first ovulation. Blockade of either trkA transducing capacity or N...

The present study was designed to explore the anti-inflammatory effect of fluvoxamine, as a selective serotonin reuptake inhibitor (SSRI) anti-depressant, on carrageenan-induced paw edema in more details. At first, fluvoxamine was administered intra-peritoneally (2.5, 12.5, 25 and 50 mg Kg(-1)) 30 min before the subplantar injection of carrageenan. Fluvoxamine was also injected intra-peritoneal...

BACKGROUND Spine stereotactic body radiation therapy (SBRT) is becoming widely accepted as first-line treatment of oligometastatic spine disease as well as in the postoperative setting. The reported incidence of myelopathy is very low and guidelines vary widely on the maximum tolerable dose of the spinal cord and thecal sac. METHODS AND MATERIALS Between April 2008 and December 2010, radiatio...

Androgens have an important role in ovarian follicular growth and function, but circulating androgen concentrations are also associated with ovarian dysfunction, cardiovascular disease, and metabolic disorders in women. The extent and causes of the variation in androgen production in individuals, however, are unknown. Because thecal cells of follicles synthesize androstenedione and testosterone...

conclusions it seems that, in patients undergoing pncl, sa is as effective and safe as ga. patients who undergo pncl under sa require smaller amounts of analgesic dose and show hemodynamic stability during surgery and recovery time. also, sa technique provides decreased blood loss and shortened surgery as well as anesthesia times compared to ga. results map and heart rate show no significant di...

Lower limb surgeries may be performed under local, regional (spinal or epidural) general anesthesia, but neuraxial blockade is the preferred mode of anesthesia. Sub-arachnoid block Spinal anaesthesia most common central used in a surgical setting, which being versatile and commonly block. With increasing use hyperbaric bupivacaine for sub arachnoid block, their limitations like prolongation ons...