Administration of intra-articular medications, including corticosteroids and analgesics, is common clinical practice for knee pathology and dysfunction. Non-steroidal anti-inflammatory drugs (NSAIDs) are another category of medication commonly prescribed for their analgesic and anti-inflammatory properties. Recent studies demonstrated the efficacy of injectable NSAIDs in the treatment of intra-...

Lornoxicam (Lnxc), a novel type of non-steroidal antiinflammatory drug developed by comely, was first listed in Denmark in October 1997 (trade name xefo). Clinically, it is used to treat rheumatoid, rheumatoid arthritis and osteoarthritis. The Lnxc with low drug concentration has a short half-life [1] after oral administration, leading to much side effect and therapy activity tended to be worse...

knee surgery. the purpose of this study was to assess the analgesic effects of intra-articular injection of a dexmedetomidine following knee arthroscopy. methods:   forty six patients schadualed for arthroscopic knee surgery under general anaesthesia, were randomly devided into two groups. intervention group received 1μg/kg dexmedetomidine (d) and isotonic saline. control group received 25ml is...

conclusions although postoperative intra-articular meperidine is a better alternative for bupivacaine, their combination could improve their analgesic effects compared with each other alone. results the bupivacaine-meperidine group had better duration of postoperative analgesia (p = 0.001), latter first analgesic request (p ≤ 0.001), lower total fentanyl consumption in first 24 hours after the ...

BACKGROUND Local administration of opioids causes effective analgesia without adverse effects related to the central nervous system. After the beneficial demonstration of peripheral opioid receptors in joint synovia, intra-articular opioid injections were used for pain treatment. Clinical studies have reported the safety and efficacy of hyaluronate injection in the shoulder joint of patients wi...

BACKGROUND Several medications are commonly injected intra-articularly for postoperative analgesia after arthroscopic knee surgery. Among the potentially efficient substances, magnesium could be of particular interest through its NMDA-receptor blocking properties. METHODS A total of 60 patients undergoing arthroscopic knee surgery were randomly and double-blindly assigned to two groups to rec...

INTRODUCTION We previously demonstrated that synovial sublining macrophages express folate receptor beta (FRβ). The aim of this study was to evaluate the efficacy of intra-articular administration of a recombinant immunotoxin to FRβ for treating rat antigen-induced arthritis. METHODS A monoclonal antibody (mAb) to rat FRβ was produced by immunizing mice with B300-19 cells (murine pre-B cells)...

CONTEXT Corticosteroid is a well-established cause of drug-induced pancreatitis. However, acute pancreatitis from intra-articular injection of corticosteroid has never been described. CASE REPORT A 69-year-old male presented with acute abdominal pain and was diagnosed with acute pancreatitis. The patient had one episode of acute pancreatitis two year earlier. Both episodes occurred after intr...

REASON FOR PERFORMING STUDY The frequent use of intra-articular triamcinolone acetonide (TA) in performance horses warrants further study of the duration of as well as the beneficial and detrimental effects on gene expression associated with administration. OBJECTIVES To assess the effects of intra-articular administration of TA on the expression of selected anti- and proinflammatory and stru...