cDNA clones encoding the murine int-1-related protein (m-irp) were isolated from an 8.5-day mouse embryo library. m-irp and its human counterpart, h-irp, share extensive nucleotide homology in coding (92%) and 3' untranslated (69%) regions. At the amino acid level, m-irp and h-irp share 97% of amino acids including all 24 cysteine residues, which are highly conserved among members of the int-1 ...

Several cellular mRNAs are regulated posttranscriptionally by iron-responsive elements (IREs) and the cytosolic IRE-binding proteins IRP-1 and IRP-2. Three different signals are known to elicit IRP-1 activity and thus regulate IRE-containing mRNAs: iron deficiency, nitric oxide (NO), and the reactive oxygen intermediate hydrogen peroxide (H2O2). In this report, we characterize the pathways for ...

BACKGROUND Despite successful treatment and CD4+ T-cell recovery, HIV-infected individuals often experience a profound immune dysregulation characterized by a persistently low CD4:CD8 T-cell ratio. This residual immune dysregulation is reminiscent of the Immune Risk Phenotype (IRP) previously associated with morbidity and mortality in the uninfected elderly (>85 years). The IRP consists of labo...

OBJECTIVE To determine the reliability of obtaining two-dimensional cephalometric measurements using two virtual head orientations from cone-beam computed tomography (CBCT) models. MATERIALS AND METHODS CBCT scans of 12 patients (6 class II and 6 class III) were randomly selected from a pool of 159 patients. An orthodontist, a dental radiologist, and a third-year dental student independently ...

Placental iron transport during the last trimester of pregnancy determines the iron endowment of the neonate. Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1). The mRNAs for TfR-1 and, potentially, FPN-1 are posttranscriptionally regulated by iron regulatory protein (IRP)-1 and IRP-2. We assessed the effect of gestationa...

Placental iron transport during the last trimester of pregnancy determines the iron endowment of the neonate. Iron transport is a function of the major iron transport proteins, transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1). The mRNAs for TfR-1, and potentially FPN-1, are post-transcriptionally regulated by iron regulatory protein-1 (IRP-1) and -2 (IRP-2). We assessed the effect of ge...

Cytokine-treated macrophages represent a useful model to unravel the molecular basis of reticuloendothelial (RE) iron retention in inflammatory conditions. In the present study, we showed that stimulation of murine macrophage J774 cells with interferon (IFN)-gamma/lipopolysaccharide (LPS) resulted in a nitric oxide-dependent modulation of the activity of iron regulatory proteins (IRP)-1 and 2, ...

‎in this paper, we present a two-stage model for ranking of decision making units (dmus) using interval analytic hierarchy process (ahp). since the efficiency score of unity is assigned to the efficient units, we evaluate the efficiency of each dmu by basic dea models and calculate the weights of the criteria using proposed model. in the first stage, the proposed model evaluates decision making...

cDNA clones encoding the murine int-1 -related protein (m-irp) were isolated from an 8.5-day mouse embryo library, m-irp and its human counterpart, h-irp, share extensive nucleotide homology in coding (92 %) and 3' untranslated (69 %) regions. At the amino acid level, mirp and h-irp share 97 % of amino acids including all 24 cysteine residues, which are highly conserved among members of the int...

Iron increases synthesis rates of proteins encoded in iron-responsive element (IRE)-mRNAs; metabolic iron ("free," "labile") is Fe(2+). The noncoding IRE-RNA structure, approximately 30 nt, folds into a stem loop to control synthesis of proteins in iron trafficking, cell cycling, and nervous system function. IRE-RNA riboregulators bind specifically to iron-regulatory proteins (IRP) proteins, in...