The morphine sparing effect of ketorolac 10 mg administered 4-hourly by intermittent i.m. injection was compared with a continuous i.m. infusion in a double-blind, placebo-controlled trial in patients undergoing upper abdominal surgery. During the 48-h postoperative period, each patient was provided with a patient-controlled analgesia (PCA) system which delivered bolus doses of morphine and adm...

Treatment of rats with either intermittent bolus i.v. injections or continuous i.v. infusions of the same sublethal daily dose of tumor necrosis factor (TNF) results in decreased food intake and decreased nitrogen balance compared to saline-treated control rats. After 4 days of treatment, rats treated with intermittent bolus doses of TNF develop tolerance to the nutritional effects and consume ...

Health technology The use of patient-controlled analgesia (PCA) for Chinese women in the first 24 hours following elective gynaecological surgery was compared with the use of intermittent intramuscular (IM) injection. A PCA machine delivered morphine intravenously by bolus, with a lockout time of 8 to 10 minutes. For IM treatment, the morphine doses were 0.1 0.2 mg/kg, with a maximum of 10 mg e...

Health technology The use of patient-controlled analgesia (PCA) for Chinese women in the first 24 hours following elective gynaecological surgery was compared with the use of intermittent intramuscular (IM) injection. A PCA machine delivered morphine intravenously by bolus, with a lockout time of 8 to 10 minutes. For IM treatment, the morphine doses were 0.1 0.2 mg/kg, with a maximum of 10 mg e...

OBJECTIVE To study the effects of continuously administered adrenaline (epinephrine), compared to bolus doses, on the dynamics of cortical cerebral blood flow during experimental cardiopulmonary resuscitation (CPR), and after restoration of spontaneous circulation (ROSC). METHODS Ventricular fibrillation was induced in 24 anaesthetised pigs. After a 5-min non-intervention interval, closed-che...

PURPOSE To compare two protocols of epidural administration of racemic methadone for postoperative analgesia (continuous infusion and intermittent bolus), focussing on plasma concentration, analgesic efficacy and side effects. METHODS Ninety patients undergoing abdominal or lower-limb surgery were randomly assigned to two groups in a prospective double-blind design. The continuous infusion pa...

We have compared intermittent bolus and continuous infusion of extradural local anaesthetic for pain relief in a randomized, double-blind study of 48 patients who underwent major abdominal gynaecological surgery. Each patient received 5 ml of 0.375% bupivacaine hourly, either as a bolus over 5 min or as a constant infusion. Patients who received the intermittent administration technique maintai...