To investigate the effect and related mechanism of propofol anesthesia on pyroptosis in neonatal rat hippocampus. Neonatal rats were divided into a control group (injected intraperitoneally with saline), 80 mg/kg propofol) propofol+MCC950 10 MCC950) administered for 5 d. The day after end drug administration, hippocampi analyzed by transferase dUTP nick labeling assay interleukin beta-1, interl...

INTRODUCTION Interleukin 1 beta (IL- 1β), a key proinflammatory cytokine encoded by the interleukin 1 beta gene, has been associated with chronic inflammation and plays an important role in lung inflammatory diseases including lung cancer. Elevated levels of Interleukin 1proteins, in particular interleukin 1 beta greatly enhance the intensity of the inflammatory response. AIM To study the rol...

Other names: Catabolin; IL-1; IL-1B; IL1-BETA; IL1F2; pro-interleukin-1-beta HGNC (Hugo): IL1B Location: 2q13 Note: IL-1beta is a pro-inflamatory cytokine and is expressed by many cells including macrophage, NK cells, monocytes, and neutrophils. It belongs to the IL-1 family cluster that includes the IL-1a, and IL1-RN genes. The caspase 1 (CASP1/ICE) gene proteolitically activates IL-1β. This g...

Keratinocytes comprise the majority of cells in the epidermis, the interleukin-1 rich layer of tissue contiguous with the outside world. Keratinocytes produce IL-1 alpha and beta mRNA in vitro, but only IL-1 alpha biological activity has been identified in keratinocyte cultures. In contrast, monocytes secrete biological activities attributable to both species of IL-1. Using several monoclonal a...

To explore the effect and molecular mechanism of total flavonoids Astragalus on apoptosis inflammation alveolar epithelial cells induced by tumor necrosis factor alpha. Human were divided into control group, alpha alpha+trifluoroacetic acid-low, acid-medium, acid-high alpha+anti-microRNA-NC alpha+microRNA-221 inhibitor acid-high+microRNA-NC acid-H+microRNA-221 mimic group. Real-time fluorescenc...