The aim of this review is to present the summarisation of the knowledge about biochemical and clinical changes that occur under the influence of asphyxia as well as about the treatment. Results of experimental works in animal models bring us the explanation about many postasphyxiated changes and help us to understand the pathophysiological changes and consequences of asphyxia. The authors prese...

Objective: Asphyxia  is  a  major  cause  of  acute  mortality  and  chronic  neurologic  disability  in  neonates. We sought to  define  the  predictive  values  of  serum  concentrations  of  interleukin-1β  in  newborns  with perinatal asphyxia to see if there is a relation between interleukin-1β (IL-1β) levels to the short term neurological deficit.  Methods: This was a prospective (case-co...

Background: Asphyxia is one the most important causes of neonatal mortality and morbidity. It is suggested that magnesium may have a protective role against cellular damage during hypoxic brain insult, or change effect post-asphyxia consequences. Our study was performed for comparison of serum magnesium in neonates with and without asphyxia.    Methods: This study was done in Neona...

Birth asphyxia is a significant global health problem, responsible for ~1.2 million neonatal deaths each year worldwide. Those who survive often suffer from a range of health issues including brain damage-manifesting as cerebral palsy (CP)-respiratory insufficiency, cardiovascular collapse, and renal dysfunction, to name a few. Although the majority of research is directed toward reducing the b...

Perinatal asphyxia (derived from Greek word a-sphyxos meaning born without an evident pulse) is one of the most important causes of fetal distress [1].Perinatal asphyxia remains a significant cause of perinatal morbidity and mortality the world over, and is known to complicate upto 5 – 10% of all deliveries[2]. A wide variety of maternal, fetal and labor conditions give rise to perinatal asphyx...

The examination of birth asphyxia from a historical perspective presents several intriguing problems. First, of course, there is no satisfactory definition. Clinicians, biochemists and pathologists all seem to use the phrase, but a universal definition is lacking. Dr. Eastman of Hopkins called asphyxia "an infelicity of etymology" since the Greek derivation of asphyxia meant "without pulse." A ...

Deaths due to plastic bag suffocation or plastic bag asphyxia are not reported in Malaysia. In the West many suicides by plastic bag asphyxia, particularly in the elderly and those who are chronically and terminally ill, have been reported. Accidental deaths too are not uncommon in the West, both among small children who play with shopping bags and adolescents who are solvent abusers. Another w...

PURPOSE To study the validity of urinary uric acid (UA) as a marker of perinatal asphyxia in term and premature infants. METHODS The urinary ratio of UA to creatinine (Cr) was obtained within 24 hours after birth in four groups of infants: 17 term infants and 18 premature infants with perinatal asphyxia, and 22 healthy term infants and 20 premature infants without perinatal asphyxia. Perinata...

We examined the neurocirculatory and ventilatory responses to intermittent asphyxia (arterial O(2) saturation = 79-85%, end-tidal PCO(2) =3-5 Torr above eupnea) in seven healthy humans during wakefulness. The intermittent asphyxia intervention consisted of 20-s asphyxic exposures alternating with 40-s periods of room-air breathing for a total of 20 min. Minute ventilation increased during the i...