Background Overall, studies of ART intensification in suppressed patients showed no reduction in HIV reservoir, as assessed by proviral DNA. Limited data about impact of ART intensification are available for failing patients harbouring multidrug resistant viruses. We studied the effects of intensification with enfuvirtide (ENF) on intracellular HIV reservoir and tropism evolution under treatmen...

BACKGROUND Among elderly patients, the management of type 2 diabetes mellitus (T2DM) is complicated by population heterogeneity and elderly-specific complexities. Few studies have been done to understand treatment intensification among elderly patients failing multiple oral antidiabetic drugs (OADs). OBJECTIVE To examine the association between time to treatment intensification of T2DM and el...

Annual land-use decisions of settlement farmers, estimated to approach half a million in the Amazon, can have significant impacts on forest conversion of the largest tropical moist forests. Given the biodiversity and climate change consequences of the disappearance of this forest, it is pivotal to understand these farmers’ reactions to combinations of technologies, policies, and institutional a...

The authors review an emerging paradigm of tropical cyclone intensification in the context of the prototype intensification problem, which relates to the spinup of a preexisting vortex near tropical storm strength in a quiescent environment. In addition, the authors review briefly what is known about tropical cyclone intensification in the presence of vertical wind shear. The authors go on to e...

OBJECTIVE To determine time to treatment intensification in people with type 2 diabetes treated with one, two, or three oral antidiabetes drugs (OADs) and associated levels of glycemic control. RESEARCH DESIGN AND METHODS This was a retrospective cohort study based on 81,573 people with type 2 diabetes in the U.K. Clinical Practice Research Datalink between January 2004 and December 2006, wit...

It is a challenge for a farmer with limited resources to decide on the production of commodities and investment in the farm. Transformation of smallholder subsistence agriculture, to market oriented value addition based agriculture is vital for poverty reduction in Ethiopia. This study was initiated to explore the factors which contribute for the adoption of improved wheat and pepper varieties ...

The purpose of this article is twofold. The first is to point out and correct several misconceptions about the putative WISHE mechanism of tropical cyclone intensification that currently are being taught to atmospheric science students, to tropical weather forecasters, and to laypeople who seek to understand how tropical cyclones intensify. The mechanism relates to the simplest problem of an in...

Effort-biased technological change and other explanations for work intensification are investigated. It is hypothesised that technological and organizational changes are one important source of work intensification and supportive evidence is found using establishment data for Britain in the 1990s. Work intensification has also been stimulated by the use of highcommitment human resource policies...

evaluation of rainfall effect on programing of agricultural management (case study: golestan region) abstract securing of water need in agricultural is important. precipitation are one of the most important of water resources in agricultural, in golestan province, especially , because alborze mountains are in golestan south. in research has investigated effects of rainfall to cropping pattern a...

BACKGROUND Combination antiretroviral therapy suppresses but does not eradicate human immunodeficiency virus type 1 (HIV-1) in infected persons, and low-level viremia can be detected despite years of suppressive antiretroviral therapy. Short-course (28-day) intensification of standard antiretroviral combination therapy is a useful approach to determine whether complete rounds of HIV-1 replicati...