The sarcoglycan sub-complex is a protein system which plays key role in sarcolemma stabilization during muscle activity consisting of six glycosylated transmembrane proteins. Integrins play the process cell adhesion, linking extracellular matrix to actin cytoskeleton. Here we have analysed receptor for thyroid hormone, identified on αvβ3-integrin that has an important activation non-genomic act...

objective(s):to examine the expressions of cd11a, cd11b, and cd11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. this study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. materials and methods: a myocardial hypertrophy model was established by subcutaneously injecting i...

there is some evidence supporting the reduced activity of integrins following chronic administration of morphine. this reduction might play a role in morphine tolerance development. manganese binds to the extracellular domain of integrins and makes them to be activated. the effect of integrins activation using manganese on tolerance development to the analgesic effect of morphine was investigat...

Abstract The bladder undergoes large shape changes as it fills and empties experiences complex mechanical forces. These forces become abnormal in diseases of the lower urinary tract such overactive bladder, neurogenic retention. As primary mechanosensors linking actin cytoskeleton to extracellular matrix (ECM), integrins are likely play vital roles maintaining smooth muscle (BSM) homeostasis. I...

Epithelial to Mesenchymal Transition The cover image shows that the malignant cells generated by epithelial-mesenchymal transition (EMT) are breaking away from benign ones and spreading elsewhere. In article number 2106498, using single-particle tracking of β1-integrins labelled with fluorescent quantum dots, Yan Wei, Peng-Ye Wang, Hui Li, co-workers discover a significantly enhanced diffusion ...

Background: Integrins are a family of transmembrane proteins that allow communication between the extracellular matrix and the interior of cells. Chondrocytes, cells of articular cartilage, express integrins and these molecules appear to have a variety of roles including mechanotransduction. Integrins are known to associate with a number of accessory molecules such as CD147 that may act to regu...