background: endometrial integrin expression changes might be a reason for implantation failure in polycystic ovarian syndromes (pcos). objective: assessment of integrin genes and proteins expression upon endometrium in the pcos experimental mouse model was the main goal of this study. materials and methods: 30 nmri female mice were equally divided into control, experimental (pcos; received estr...

Introduction: Skeletal muscle is a flexible and ever changing tissue and the role of costameric proteins in its response to different stimuli is not well defined. The aim of this study was to investigate the effect of progressive resistance exercise on β1 integrin and vinculin proteins in fast and slow twitch skeletal muscles of male rats. Methods: Twelve male Wistar rats (weight: 298±5.2 gr...

introduction: the implantation is a complex procedure that involves many molecules. one of these molecules is integrin specially &alphav;&beta3; which serves as receptor for components of extra cellular matrix to act as bridging molecules between the blastocyst and the endometrial surface during the implantation process. by blocking &alphav;&beta3; interactions, the implantation can be impaired...

background: it has been hypothesized that blastocyst integrin expression changes can affect the spontaneous miscarriage in polycystic ovarian syndromes (pcos). objective: in this study, the profile of integrin genes and proteins was investigated on blastocyst of the pcos experimental mouse model. materials and methods: 30 nmri female mice were equally divided into 3 groups: control, experimenta...

background: pinopodes are suggested as biological markers of uterine receptivity, but their molecular components are unknown. objective: co-expression of galectin-3 and ?v?3 integrin at human pinopodes has been examined in this study to propose a role for them during adhesion phase of embryo implantation. materials and methods: biopsies were obtained from early and mid luteal phase endometrium ...

background: recent studies have provided evidence that integrins play roles in recognition of mechanical stimuli and its translation into a cellular response. integrin signaling may be regulated by a number of mechanisms including accessory proteins such as cd98 (4f2 antigen). objectives: to determine cd98 expression by human articular chondrocytes and its involvement in human articular mechano...

objective(s):to examine the expressions of cd11a, cd11b, and cd11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. this study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. materials and methods: a myocardial hypertrophy model was established by subcutaneously injecting i...

inflammation of blood vessels is a characteristic feature of kawasaki disease. neutrophils play a key role in the inflammatory responses where movement of neutrophils toward the site of inflammation depends on cd11b/cd18 expression as adhesion molecules on these cells. the purpose of this study was to investigate cd11b/cd18 expression in patients with kawasaki disease upon diagnosis and after t...

Integrin receptors are essential contributors to neurite outgrowth and axon elongation. Activated integrins engage components of the extracellular matrix, enabling growth cone form point contacts, which connect substrate dynamic intracellular protein complexes. These adhesion complexes facilitate efficient migration extension. Major signalling pathways mediated by complex instigated focal kinas...

Basophils co-express FcεRIα and CD49b, the α-2 chain of integrin-type receptor VLA-2 (α2β1), which recognizes type-1 collagen as a major natural ligand. The physiological relevance of this integrin for interactions with extracellular bone marrow matrix remains unknown. Herein, we examined the expression of several receptors of this family by bone marrow-derived basophils sorted either ex-vivo o...