On page 1077, Machado et al. reveal a new way in which aspirin reins in inflammation— it triggers the destruction of proinflammatory signaling proteins. Aspirin's power was initially attributed to its inhibition of proinflammatory lipids called prostaglandins— a discovery that won the Nobel Prize in 1982. Later, aspirin was also shown to beef up levels of lipids called lipoxins, which help reso...