OBJECTIVE Present study aimed at further comprehensive functional, histomorphometrical and immunohistochemical assessment of peripheral nerve regeneration using rat sciatic nerve transection model. METHODS The 10-mm rat sciatic nerve gap was created in rats. In control group nerve stumps were sutured to adjacent muscle and in treatment group the gap was bridged using an inside-out vein graft....

This paper presents the application of the adaptive neuro fuzzy inference system (ANFIS) to a model of the flow field inside an in vitro arteriovenous (AV) graft-to-vein connection implanted to the kidney patients. A model based on ANFIS is proposed. Its relevant steps oriented to find the optimal AV graft angle are given. The advantage of this neuro-fuzzy hybrid approach is that it does not re...

ObjectiveAdipose tissue is an appropriate source for isolation of cells with stem-cell–like properties. In the present long-term study, the effects of the omental adipose-derived nucleated cells (OADNCs) fraction were compared to those of the undifferentiated cultured bone marrow stromal cells (BMSCs) on sciatic nerve regeneration. DesignExperimental in vivo study. AnimalsFifty male White Albin...

We attempted transplantation of adult neural stem cells (ANSCs) inside an autologous venous graft following surgical transsection of nervis cruralis with 30 mm long gap in adult pig. The transplanted cell suspension was a primary culture of neurospheres from adult pig subventricular zone (SVZ) which had been labeled in vitro with BrdU or lentivirally transferred fluorescent protein. Lesion-indu...

Background: Peripheral vascular injury associated with lower limb trauma is a well-known emergency. The experience for the management of popliteal artery trauma have mainly come from managing the traumas of military personnels during Iran-Iraq war. The present study compared the effects of two currently-used surgical techniques in the management of popliteal trauma, namley femoropopliteal bypas...

OBJECTIVE To evaluate direct versus indirect monocyte chemoattractant protein (MCP)-1/CCR2 signaling and to identify the cellular producers and effectors for MCP-1 during neointimal hyperplasia (NIH) development in vein grafts. METHODS AND RESULTS Genomic analysis revealed an overrepresentation of 13 inflammatory pathways in wild-type vein grafts compared with CCR2 knockout vein grafts. Furth...

Results One patient with subclavian artery aneurysm underwent resection of the aneurysm and subclavian-axillary bypass surgery with brachial embolectomy using a polytetrafluoroethylene (PTFE) graft; whereas the other patient underwent resection of the aneurysm and subclavian-axillary bypass surgery with saphenous vein graft. In addition to resection of the aneurysm, three out of 6 patients with...