Fungal infections and antifungal resistance are increasingly recognized. Antifungal susceptibility testing remains unstandardized, and a particularly important problem is endpoint determination. In this paper we propose the yeast metabolic reduction of the tetrazolium salt 2,3-bis(2- methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetraz olium hydroxide (XTT) as a colorimetric endpo...

Antimicrobial resistance has emerged as one of the most-significant health care problems of the new millennium, and the clinical microbiology laboratory plays a central role in optimizing the therapeutic management of patients with infection. This minireview explores the potential value of innovative methods for antimicrobial susceptibility testing of microorganisms that could provide valuable ...

This study is about outlier detection in time series data. The main objective is to derive and to test statistics for detecting additive outlier (AO) and innovative outlier (IO) in GARCH(1,1) processes and subsequently to develop a procedure for testing the presence of outliers using the statistics. A test statistic has been derived for each type of outlier. In the derivation of the statistics,...

Human genome-wide association studies (GWAS) have successfully identified thousands of susceptibility loci for common diseases with complex genetic etiologies. Although the susceptibility variants identified by GWAS usually have only modest effects on individual disease risk, they contribute to a substantial burden of trait variation in the overall population. GWAS also offer valuable clues to ...

We have developed a rapid microfluidic method for antibiotic susceptibility testing in a stress-based environment. Fluid is passed at high speeds over bacteria immobilized on the bottom of a microfluidic channel. In the presence of stress and antibiotic, susceptible strains of bacteria die rapidly. However, resistant bacteria survive these stressful conditions. The hypothesis behind this method...

The Colorado potato beetle (CPB) and the western corn rootworm (WCR) are among world’s most expansive insect pests. aim of study was to assess, for first time in Poland, levels susceptibility to deltamethrin tau-fluvalinate WCR determine current status those active substances CPB. In addition, role oxidative metabolism detoxification pyrethroids was determined using piperonyl butoxide (PBO...

Market transformation of post-socialist countries was accompanied by innovative activity slowdown against the background of considerable economic recession and further crisis. The former economic system was characterized by selective approach to the innovations. Particularly, in the former Soviet Union, including Ukraine, demand on the innovations within military-industrial complex prevailed. I...