نتایج جستجو برای: inhibitor protein
تعداد نتایج: 1363521 فیلتر نتایج به سال:
abstract ethanol has a vast consumption around the world. many researches confirmed some adverse effect of this component on human health. in addition, recent studies showed significant alteration in both cellular population, and protein profile of human foreskin fibroblast cell line (hfff2) in the specific dosage of ethanol. here, the role and interaction of some proteins (characterized by sig...
abstract background: oligodendrogliomas are sub-types of gliomas with an enriched net of branching capillary. a vast amount of oligodendroglial (approximately 60-90%) demonstrates a loss of 1p and 19q chromosomes, and their response to radio and chemotherapy treatments are considerably more favorable and less aggressive. rho gdp inhibitor is a protein which controls the activity and distributio...
Aims: This paper aimed to investigate the antiviral drugs against Sars-Cov-2 main protease (MPro) using in silico methods.
 Material and Method: A search was made for PubChem database such as Bictegravir, Emtricitabine, Entecavir, Lamivudine, Tenofovir, Favipiravir, Hydroxychloroquine, Lopinavir, Oseltamavir, Remdevisir, Ribavirin, Ritonavir were included our study. The protein structure o...
background: angiogenesis is an important process in various physiologic and pathologic states. the most significant stimulator of angiogenesis is vascular endothelial growth factor (vegf). in contrast, vasohibin1 acts as an angiogenesis inhibitor which specifically inhibits new vessels formation. the aim of the present study was cloning and expression of vasohibin1 gene in e. coli as well as pu...
Background and Objective: Salubrinal- a protein synthesis inhibitor- plays a crucial role in sleep and neuronal inhibition through the GABA activation. According to these evidences, the aim of the present study was to determine the effect of salubrinal on epileptic seizures induced by pentylenetetrazol (PTZ). Materials and Methods: In this expremental study under stereotaxical surgery,...
Abstract Background and Objective: Resistance to antiretroviral agents is a significant concern in clinical management of HIV-infected individuals. Resistance is the result of mutations that develops in the viral protein targeted by antiretroviral agents. Material and Methods: In this cross-sectional study, the blood samples of 40 HIV-positive patients were collected. Twenty of them were d...
Bromodomain and extra-terminal domain inhibitors target bromodomain-containing proteins are currently being evaluated as anti-cancer agents. In this study, we found that bromodomain extraterminal inhibitor OTX015 can effectively inhibit the proliferation of hepatocellular carcinoma cells promote apoptosis cells. At same time, anticancer effect is better than JQ1, a similar inhibitor. addition, ...
Background and Objective: Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases and results from the extracellular accumulation of b-amyloid peptides and the resulting neuronal dysfunction. In this study, the role of nicotinic acetylcholine receptors, protein kinase B (PKB) and protein kinase M (PKM) were evaluated in order to examine the mechanism of the protective effe...
abstract background and objective: highly active antiretroviral therapy (haart) can effectively prevent the progression of hiv-1 replication and increase life expectancy. there are numerous causes of treatment failure and the leading one is drug resistance. thus, we aimed to determine the hiv rt gene drug resistance mutations in patients treated with antiretroviral medications. material and met...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید