After a non-inferiority margin is established, a prospective non-inferiority trial is usually conducted to confirm the noninferiority of the new product when compared to the existing product. Non-inferiority trials typically require considerably larger sample sizes than placebo-controlled trials [4]. This is due to the fact that the margin of equivalence (non-inferiority) is often much smaller ...

abstract background: infertility and the reactions of people towards it can lead to psychological disorders which have negative effects on the life of young couples. therefore, this study aims to comparatively analyze the level of mental health, happiness, inferiority feelings, sexual satisfaction and marital conflict in fertile and infertile women in kermanshah. methods: this cross-sectional s...

This article traces disagreements about the genetic effects of low-dose radiation exposure as waged by James Neel (1915-2000), a central figure in radiation studies of Japanese populations after World War II, and Yuri Dubrova (1955-), who analyzed the 1986 Chernobyl nuclear power plant accident. In a 1996 article in Nature, Dubrova reported a statistically significant increase in the minisatell...

Everyone starts life with some feelings of inferiority. Subsequent success or failure is determined by the ability to adjust the inferiority feeling to the demands of life. Normal development requires the recognition of one’s limitations and capacities in order to achieve a profitable balance in emotional maturity. The inferiority complex is different from the inferior feeling of which the form...

New treatments that are potentially as effective as existing treatments are increasingly being developed, some of which may be preferred because of lower cost, fewer side effects, easier administration or less harm. Non-inferiority trials attempt to establish whether or not a new treatment -- drug or non-drug -- is no worse than an established treatment for which efficacy has been determined in...

BACKGROUND Non-inferiority trials are performed when the main therapeutic effect of the new therapy is expected to be not unacceptably worse than that of the standard therapy, and the new therapy is expected to have advantages over the standard therapy in costs or other (health) consequences. These advantages however are not included in the classic frequentist approach of sample size calculatio...

AIM To determine the association between feelings of inferiority and suicidal ideation and suicide attempt among youth in the United States. METHODS Data were drawn from the National Comorbidity Survey carried out among a representative sample of the 15-54 year old population (n=8,098) in the United States. The subsample analyzed in this study included 1,456 respondents aged 15-19. Multivaria...