Objective(s): Mutations in the UGT1A1 gene are responsible for hyperbilirubinemia syndromes including Crigler-Najjar type 1 and 2 and Gilbert syndrome. In view of the genetic heterogeneity and involvement of large numbers of the disease causing mutations, the application of polymorphic markers in the UGTA1 gene could be useful in molecular diagnosis of the disease. Materials and Methods: In the...

Background: DNA markers are inevitable tools of human identification in forensic science. Single Nucleotide Polymorphisms (SNPs) are one category of these markers which is concerned to use especially in the case of degraded DNA because of their short amplicons. Objectives: Detection of highly informative SNPs by the criteria is the essential step to devel...

microsatellite markers were used to identify informative markers associated with traits lattice shape of pod, belly shape in pod, pod length, pod width, grain number per pod, grain weight, grain weight/pod weight, grain length, grain width, pod number per plant, grain number per plant, pod weight per plant, grain weight per plant in peanut. thirteen ssr primer pairs amplified 80 alleles among 6...

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic nephropathy, which is characterized by replacement of renal parenchyma with multiple cysts. In Iran, the disease prevalence within the chronic hemodialysis patient population is approximately 8-10%. So far, three genetic loci have been identified to be responsible for ADPKD. Little information is available concernin...

Background: Indirect genetic diagnosis using polymorphic DNA markers can detect carriers of hemophilia A. This technique is preferable in developing countries because of its simplicity and cost effectiveness compared to direct mutation analysis. In the present study, we examined usefulness of intragenic marker BclI restriction fragment length polymorphism (RFLP) at intron 18, for carrier detect...

this study was performed for assessment of correlation of 11 morphological traits with rapd molecular markers in 15 cultivars of date palm collected from the south and south west of iran as population analysis by stepwise regression method. the results of simple and multiple regressions showed that in sum 84 rapd markers had significant association with at least one of the traits. the coefficie...

background: indirect genetic diagnosis using polymorphic dna markers can detect carriers of hemophilia a. this technique is preferable in developing countries because of its simplicity and cost effectiveness compared to direct mutation analysis. in the present study, we examined usefulness of intragenic marker bcl i restriction fragment length polymorphism (rflp) at intron 18, for carrier detec...