Background & Objectives: Stress response to extensive surgeries in cancer patients results an imbalance between the pro-inflammatory and anti-inflammatory cytokines, besides activating inflammatory cascade. We investigated comparative effects of intravenous infusion dexmedetomidine lidocaine on proinflammatory cytokines stress reaction.
 Methodology: A prospective randomized double bli...

AIM We examined the effect of proinflammatory and anti-inflammatory interleukins on jejunal nutrient transport and expression of the sodium-glucose linked cotransporter (SGLT-1). METHODS 3-O-methyl glucose and L-proline transport rates were examined in New Zealand White rabbit stripped, short circuited jejunal tissue. The effects of the proinflammatory cytokines interleukin (IL)-1alpha, IL-6,...

BACKGROUND Cytokines play an significant role in regulating non-specific inflammatory response involved in many pathological processes. The current study tested the hypothesis that myocardial infarction in patients with obesity can lead to increased production of proinflammatory cytokines and unfavorable course of the pathological process. METHODS The study recruited 232 male patients with ST...

BACKGROUND Organic inflammatory response is a pathophysiological mechanism present at every coronary artery bypass grafting with extracorporeal circulation (CABG-ECC), the release of inflammatory mediators being one of its defense mechanisms. OBJECTIVE To assess, in a prospective double-blind randomized and placebo-controlled study, the effects of trimetazidine (Tmz) on the inflammatory respo...

Abstract Cardioplegia and exposure to the heart-lung machine required in cardiopulmonary bypass induce a systemic inflammatory response. Adverse effects cause longer ICU stays, higher medical costs, worsened mortality morbidity, especially neonatal pediatric populations. nCPCs have been shown regenerative anti-inflammatory properties when introduced animal studies as treatment. Surgeons at UMB ...

background: acute blood purification (abp) therapy is used regularly in the clinical setting and reportedly alleviates organ failure associated with severe systemic inflammatory responses, leading to reduced mortality. the present study aimed to determine whether there is a difference in efficacy between polysulfone (ps) membranes, which are currently used regularly in the clinical setting, and...

background: multiple sclerosis (ms) is known as a progressive central nervous system inflammatory disease. certain factors, such as interleukins, inflammatory cells, and oxidative stress are supposed to involve in ms etiology. because of the important role of oxidative stress, antioxidant therapy for ms has received more attention. although coenzyme q10 (coq10) acts as an antioxidant, there is ...

Psoriasis is a common chronic inflammatory skin disease that is mediated, in part by the body's T-cell inflammatory response mechanisms. Further insight into the pathogenesis of the disease and the role of various cytokines, particularly interleukin(IL)-12 and IL-23, has led to advances in the treatment of this disease. A relatively new class of drugs that inhibit these interleukins is being de...

Skin depigmentation phenomena, caused by the loss of melanocytes, are the distinctive feature of vitiligo. The inner mechanisms of melanocyte loss are still unclear; however, an increasing number of basic and clinical observations highlighted the fundamental role of cellular immunity, chronic inflammatory phenomena and intercellular cross-talk breakdown in vitiligo pathogenesis. The modulation ...