the immunopathology of sarcoidosis remains elusive despite years of research into this multiorgan disease.however, recent studies have provided new insights into the genetics and immune components involved in the clinical manifestation of the disease. granulomatous inflammation is due to the host immune response to a persistent poorly degradable unknown antigen.mycobacterium tuberculosis (mtb) ...

background:  sternocostoclavicular joint (sccj) swelling is an underdiagnosed, albeit important entity in clinical practice. the present study was conducted in order to identify the incidence and common causes of this entity.  methods:  patients presenting to the orthopaedic clinic with a swelling of the sternocostoclavicular joint, during the study period of two years were included, and detail...

inflammatory myofibroblastic tumor (imt) is a rare neoplastic lesion with tendency toward local aggressive behavior and recurrence. the tumor most commonly occurs in the pulmonary system of children and young adult, although it may rarely develop in older patients and other organs. symptoms are non-specific and depend on the location of the tumor. the gastrointestinal tract is rarely the primar...

introduction: about one third of the world's population is infected with tuberculosis (tb) and each year, about 1.5 to 2 million people die from tb. procalcitonin (pct) is an inflammatory marker that its level has variable materials and methods: this conducted on patients with pulmonary tb. data were collected using a check list. the serum level of pct was measured by elisa test at the beg...

atrial fibrillation (af) is associated with inflammatory and hypercoagulability state. previous studies evaluated the safety and efficacy of dabigatran and warfarin in prevention of thrombothic complications. this study was intended to assess the influence of these drugs on hemostatic and inflammatory markers among patient underwent pulmonary vein ablation.   a total of 100 patients with af who...

background and objective: inflammatory pseudotumor  is a lesion composed of proliferating spindle cells with mixed inflammatory infiltrates. some authors have proposed the name inflammatory myofibroblastic tumor as a proper descriptive term rather than the vague inflammatory pseudotumor. the aim of this study was to verify the myofibroblastic origin of spindle cells in idiopathic orbital inflam...

neuroinflammation is inflammation of the nervous tissue. it be initiated in response to infection, toxic metabolites, auto immunity, traumatic brain injury and variety of causes. exercise is a promising mechanism of prevention and treatment for disease characterized by neuroinflammation. the benefits of exercise and physical activity (pa) are well known and have effects on function of the centr...

asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active drugs. to solve this paradox, we need objective airway biomarkers to tailor the proper medica...

fecal calprotectin is released in colon by activated neutrophils. investigation of diagnostic application of determination of fecal calprotectin levels is considered by many researchers to compare between different colorectal diseases like irritable bowel syndrome (ibs) and inflammatory bowel diseases (ibd). due to the effect of nutrition habits on the inflammatory processes of bowel, the main ...

background: patients with bleeding disorders are frequently infected with hepatitis c virus (hcv). there are few reports on the effect of standard interferon in these patients and no published report on pegylated interferon. the aim of this study was to compare pegylated interferon alpha-2a and standard interferon alpha with ribavirin in patients with bleeding disorders and chronic hcv infectio...