Acute lymphoblastic leukemia (ALL) in infants under 12 months of age accounts for about 4% of childhood ALL and differs from ALL in older children with respect to immunophenotypic, cytogenetic and molecular genetic features. In contrast to the predominance of male sex in older children with ALL, there is a slight predominance of girls in infant ALL (1). In infant leukemia, all necessary genetic...

background : we conducted the present study to investigate the frequency of prothrombin g20210a mutation among acute lymphoblastic leukemia patients and healthy individuals from western iran and to detect the possible association between this mutation and the risk of acute lymphoblastic leukemia in our population. methods : the studied groups consisted of 92 children with acute lymphoblastic le...

recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. to evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. the polymorphisms of genes encoding carcinogen-metabolizing ...

adipose tissue secretes a large number of adipocytokines such as leptin, resistin, and adiponectin. many of these hormones and cytokines are altered in obese individuals and may lead to disruption of the normal balance between cell proliferation, differentiation, and apoptosis. the aim of our work was to investigate the disturbance of secretion of adiponectin and resistin in de novo and relapse...

acute lymphoblastic leukemia (all) is a malignant disorder of lymphoid precursor cells, which could be classified according to morphological and cytochemical methods as well as immunophenotyping. twenty patients with all, who had been referred to the children's medical center hospital, during the year 2007, were enrolled in this study in order to evaluate the morphologic and immunophenotypic pr...

hypercalcemia in children is a medical emergency and often manifests as nonspecific symptoms such as nausea, vomiting, weight loss, and anorexia. severe hypercalcemia is a rare complication of malignancy in children, while it can be seen in various types of malignant tumors. it is usually associated with significant morbidity and may be severe enough to threaten life. incidence of hypercalcemia...

Introduction: The objective of this study is to determine the major causes of early death in acute lymphoblastic leukemia (ALL).  Methods: The following databases including PubMed, EMBASE, Science Direct and Google Scholar were searched for following terms: “acute lymphoblastic leukemia”, “early mortality”, “early death “ and “death in induction phase “. Inclusion criteria were all studies abo...

Acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. The conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. It has been rarely reported in the literature. In leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. Herein, we rep...

Recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. The polymorphisms of genes encoding carcinogen-metabolizi...

acute lymphoblastic leukemia (all) is one of the most common cancers among children. although there have been tremendous treatments, none of them have led to a precise cure. the use of herbal medicines which are safe and non-toxic have been demonstrated in this study. curcumin is a polyphenol, hydrophobic product that is derived from turmeric plant. curcumin has anti-toxic, anti-bacterial, anti...