The study was aimed at evaluating therapeutic efficacy of vitamin D3 (VD3, 1000 IU/kg b.w., 30 days) and sodium salt methylenebisphosphonic acid (MBPA, 17 mg/kg monotherapies as well their effect in combination preventing mineral metabolism bone remodeling disturbances associated with glucocorticoid(GC)-induced osteoporosis. Osteoporosis rats induced by long-term (30 administration the syntheti...

1. Apply an understanding of drug mechanisms to explain drug-induced osteoporosis and its consequences. 2. Use the diagnostic process to develop treatment and monitoring plans for drug-induced osteoporosis. 3. Assess for potential risk factors associated with druginduced osteoporosis. 4. Evaluate the epidemiologic literature to assess the absolute increase in risk of drug-induced osteoporosis a...

The current study aimed to improve the understanding on the association between adrenomedullin and osteoporosis in mice with glucocorticoid-induced osteoporosis. Bone resorption and osteoporosis-associated indexes, including maximum load, stiffness, energy to failure, ultimate strength, elastic modulus, post-yield displacement and post-yield displacement, in mice with osteoporosis were analyzed...

Objective(s): The prognosis of osteoporosis is very poor, and it is very important to identify a biomarker for prevention of osteoporosis. In this study, we aimed to identify candidate markers in osteoporosis and to investigate the role of candidate markers in osteogenic differentiation. Materials and Methods: Using Weighted Gene Co-Expression Network analysis, we identified three hub genes mig...

Diabetes osteoporosis is a common secondary bone Metabolic disorder, which seriously affects the quality of life patients. Traditional Chinese medicine categorizes it as "diabetes" combined with "bone dysfunction". Through consulting related literature diabetes induced osteoporosis, this paper summarized TCM understanding disease, etiology and pathogenesis, syndrome differentiation treatment, c...

Aim: The aim of this study was to compare two different models of osteoporosis radiographically and histopathologically and evaluate the effect of osteoporosis on alveolar bone. Methods: Twenty two rats were involved in this study. Study groups are; Control (C, n=6) group; retinoic acid-induced osteoporosis group (EG-1, n=8) and bran bread-induced osteoporosis group (EG2, n=8). Retinoic acid in...

Osteoporosis is a metabolic bone disease characterized by low bone mass, impaired micro-architecture and susceptibility to fracture. Osteoporosis may be, inter alia, a result of a long-term glucocorticosteroid therapy, e.g. with prednisolone. Although a number of properties of prednisolone in influencing bone metabolism have been recognized, the effect of prednisolone-induced osteoporosis on th...

BACKGROUND Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. OBJECTIVE It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. MATERI...