background: stearic acid is known as a potent anti-inflammatory lipid. this fatty acid has profound and diverse effects on liver metabolism. the aim of this study was to investigate the effect of stearic acid on markers of hepatocyte transplantation in rats with acetaminophen (apap)-induced liver damage. methods: wistar rats were randomly assigned to 10-day treatment. stearic acid was administe...

conclusions in conclusion, at measurement can be beneficial for the safety or recovery of malathion-induced toxic injury in liver tissue and liver mitochondria. results in liver tissue, the activity of lpo and cat was higher in the malathion group in comparison to controls. at reduced malathion-induced lpo, sod, cat, and gpx in rat liver. coadministration of at with malathion improved lpo, sod,...

Objective(s): Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods: Mic...

Herb Induced Liver Injury (HILI) is a condition in which there aggression to the liver tissue after exposure substances present many different medications, dietary supplements, herbs and xenobiotics.

liver injury occurs with many drugs; therefore, a thorough work up is important for establishing the diagnosis. we report a case of trifluoperazine-induced cholestatic jaundice. a 44-year old male with schizoaffective disorder developed an increase in liver enzymes and jaundice after starting treatment with trifluoperazine. workup for other potential etiologies was negative.

Objective(s):Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. Materials and Methods: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated d...

Objective(s): The objectives of the current study were to evaluate the effects of hepatic ‎ischemia/reperfusion (IR) injury on the activity of antioxidant enzymes, biochemical factors, and ‎histopathological changes in rat kidney, and to investigate the effect of crocin on IR-‎related changes. Materials and Methods: Thirty-two male Wistar rats were randomly allocated into four groups (n=8). The...

: Cardiopulmonary surgery is associated with risk of liver dysfunction due to hypoperfusion, release mediators by macrophages and drug induced injury.

objective(s): the aim of the present study is to determine the effect of chloramphenicol (cap) on rat liver and small intestine. effect of phenobarbital (pb) on cap toxicity was also investigated.   materials and methods:   rats were received cap at doses of 0, 200, 400 and 600 mg/kg. another group was pretreated with 80 mg/kg pb 30 min prior to administration of various doses of cap. the exper...