background: chest tube removal is a painful procedure. the goal of this study was to evaluate the effect of cold application incombination with indomethacin suppository on chest tube removal pain in patients undergoing open heart surgery. materials and methods: this single-blind, double-group clinical trial was performed on 66 patients aged 18-68 years with thechest tube in pleural space. the i...

OBJECTIVE This study was conducted to estimate the incidence and clinical predictors of post-thoracotomy shoulder pain and to determine the effectiveness of thoracic epidural block in alleviating this pain. DESIGN A prospective clinical trial. SETTING University teaching hospital. PARTICIPANTS AND INTERVENTIONS Thirty-two adult patients undergoing elective thoracic surgery consented to pa...

OBJECTIVE To evaluate the effect of pre-operative indomethacin suppository on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. STUDY DESIGN A double blind placebo-controlled randomized clinical trial. PLACE AND DURATION OF STUDY Hazrat Rasoul Akram Hospital, Tehran, Iran, from February 2010 to September 2012. METHODOLOGY One hundred and thirty patient...

In Bangladesh about nineteen different Indomethacin marketed preparations (including capsule and suppository) are available. Of them nine brands dosage forms, potency of which was assayed by UV spectrophotometry dissolution study carried out according to the USP pharmacopoeial method evaluate their quality. The result showed that eight capsules (89%) met specification remaining one brand less p...

Background. Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain. Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are both used as first-line choices in its management. Aim. This study aimed to compare the efficacy and safety of opioids and NSAIDs in the management of acute renal colic. Methods. One hundred and fifty-eight patients were divided ...

We prepared indomethacin (IM) sustained-release suppositories using sugar ester (SE) as an additive. The suppositories were prepared by the fusion method with IM, SE, and Witepsol H-15 (H-15) and their availabilities in vitro and in vivo were evaluated mainly by the drug release test and the absorption test in rabbits, respectively. The softening point of the suppositories increased with increa...