The kinetics of formation and persistence of 7-ethylguanine (e7Gua) and O6-ethylguanine (O6eGua) were determined in rat liver and kidney DNA following i.p. injection with 12.5, 50, 100, or 200 mg DENA per kg body weight. The rate of ethylguanine formation in hepatic DNA was independent of carcinogen dose; however, the maximum level of DNA ethylation reached was linearly related to DENA dose. Pe...

Tumors of the liver, kidneys, and lungs have been induced in rats by the feeding of dimethyl nitrosamine (DMN) and diethylnitrosamine (DENA) (1, 11, 12, 18). Dontenwill et al. (3, 4) reported that squamous-cell carcinoma of the trachea and lung of Syrian hamsters followed ad ministration of DENA by each of three ap proaches—tube feeding, inhalation, and subcu taneous injection. They observed ...

Background: Diethylnitrosamine (DENA) is dietary carcinogen. It known as cancer initiator in various organs. The present study investigated the destructive changes of DENA liver and colon possible therapeutic effects doxorubicin (DOX); pyridazine derivative (MDP) lactobacillus casei (LAB) against induced dysplasia colon.Methods: Lactobacillus were tested for their probiotic properties prepared ...

Tumors of the liver, kidneys, and lungs have been induced in rats by the feeding of dimethyl nitrosamine (DMN) and diethylnitrosamine (DENA) (1, 11, 12, 18). Dontenwill et al. (3, 4) reported that squamous-cell carcinoma of the trachea and lung of Syrian hamsters followed ad ministration of DENA by each of three ap proaches—tube feeding, inhalation, and subcu taneous injection. They observed ...

The influence of pasteurization and sodium chloride, sodium ascorbate, polyphosphates and sodium nitrite coupled with pasteurization on nitrosamine contents in pork was studied. Nitrosamines: dimethylonitrosamine (DMNA) and diethylonitrosamine (DENA) were extracted from raw material, distilled, condensed in an evaporator under lowered pressure and analyzed chromatographically. An inhibitory eff...

Liver cancer remains one of the severe lethal malignancies worldwide and hepatocellular carcinoma (HCC) is the most common form. The current study was designed to evaluate the prophylactic role of the fruit of Averrhoa carambola (star fruit or Kamrak) on diethylnitrosamine- (DENA-) induced (15 mg/kg b.wt.; single i.p. injection) and CCl4-promoted (1.6 g/kg b.wt. in corn oil thrice a week for 24...

Tumors of the liver, kidneys, and lungs have been induced in rats by the feeding of dimethyl nitrosamine (DMN) and diethylnitrosamine (DENA) (1, 11, 12, 18). Dontenwill et al. (3, 4) reported that squamous-cell carcinoma of the trachea and lung of Syrian hamsters followed ad ministration of DENA by each of three ap proaches—tube feeding, inhalation, and subcu taneous injection. They observed ...

the nnw-trending dena fault, with 140 km length, cuts the major structures of zagros fold-thrust belt in borujen region. the fault has divided the region in two zones, in which different structural, andmorphological features as well assedimentation and seismtectonic characteristics have developed. this study presents a new interpretation for the kinematics of dena fault based on field evidence....

Diethylnitrosamine (DENA) was administered with drinking water (40 mg/liter) to male Wistar rats for 4, 6, 8, and 10 weeks. The protein:DNA ratio and the ultraviolet light spectral properties of liver chromatin were not modified by DENA treatment. Nonhistone proteins were separated by sodium dodecyl sulfate:polyacrylamide electrophoresis on slab gels and analyzed by densitometry with a scanning...

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, and chemoprevention represents a viable approach in lowering the mortality of this disease. Pomegranate fruit, an abundant source of anti-inflammatory phytochemicals, is gaining tremendous attention for its wide-spectrum health benefits. We previously reported that a characterized pomegranate emulsion (...