نتایج جستجو برای: ina
تعداد نتایج: 1934 فیلتر نتایج به سال:
Controlled ice nucleation is an important mechanism in cold-hardy plant tissues for avoiding excessive supercooling of the protoplasm, for inducing extracellular freezing and/or for accommodating ice crystals in specific tissues. To understand its nature, it is necessary to characterize the ice nucleation activity (INA), defined as the ability of a tissue to induce heterogeneous ice nucleation....
AIMS Enhanced cardiac late Na current (late INa) and increased sarcoplasmic reticulum (SR)-Ca(2+)-leak are both highly arrhythmogenic. This study seeks to identify signalling pathways interconnecting late INa and SR-Ca(2+)-leak in atrial cardiomyocytes (CMs). METHODS AND RESULTS In murine atrial CMs, SR-Ca(2+)-leak was increased by the late INa enhancer Anemonia sulcata toxin II (ATX-II). An ...
Recent evidence indicates that polyunsaturated long-chain fatty acids (PUFAs) prevent lethal ischemia-induced cardiac arrhythmias in animals and probably in humans. To increase understanding of the mechanism(s) of this phenomenon, the effects of PUFAs on Na+ currents were assessed by the whole-cell patch-clamp technique in cultured neonatal rat ventricular myocytes. Extracellular application of...
Wintering flower buds of cold hardy Rhododendron japonicum cooled slowly to subfreezing temperatures are known to undergo extraorgan freezing, whose mechanisms remain obscure. We revisited this material to demonstrate why bud scales freeze first in spite of their lower water content, why florets remain deeply supercooled and how seasonal adaptive responses occur in regard to extraorgan freezing...
BACKGROUND Slowed Na⁺ current (INa) decay and enhanced late INa (INa-L) prolong the action potential duration (APD) and contribute to early afterdepolarizations. Cardiac resynchronization therapy (CRT) shortens APD compared with dyssynchronous heart failure (DHF); however, the role of altered Na⁺ channel gating in CRT remains unexplored. METHODS AND RESULTS Adult dogs underwent left-bundle br...
INA (that stands for Institut National de l’Audiovisuel) is the French institute in charge of the archiving for radio and television. INA archives programs broadcasted by the French public radio or TV channels. But INA is also in charge of the legal deposit for Audiovisual: INA archives a selection of all programs broadcasted in France, be they by private or public channels. As a consequence, I...
The majority of Na channels in the heart are composed of the tetrodotoxin (TTX)-resistant (KD, 2 to 6 micromol/L) "cardiac" NaV1.5 isoform; however, TTX-sensitive (KD, 1 to 25 nmol/L) "neuronal" Na channel isoforms have recently been detected in several cardiac preparations. In the present study, we determined the functional subcellular localization of Na channel isoforms (according to their TT...
برخی از باکتری های بیماری زای قسمت های هوایی گیاهان، قابلیت عمل کردن به عنوان هسته یخ در دماهای 5/1 تا 9 درجه زیر صفر (5/1- تا 9-) را داشته و هر ساله خسارت های زیادی را در اثر یخ زدگی، به مزارع و باغات اکثر کشورهای دنیا وارد می سازند. تحقیق اخیر به منظور شناسایی ژن مسئول بیوسنتز پروتئین عامل یخ زدگی (ژن ice) در جدایه هایی از باکتری غالب در مرکبات و تعداد دیگری از میزبان ها در فصول خنک سال در ما...
INTRODUCTION Fever can increase the susceptibility to supraventricular and ventricular arrhythmias, in which sodium channel dysfunction has been implicated. Whether fever influences the efficacy of sodium channel blocking drugs is unknown. The current study was designed to investigate the temperature dependent effects of distinct sodium channel blocking drugs on the sodium currents in human ind...
The sodium current in the heart is not a single current with a mono-exponential decay but rather a mixture of currents with different kinetics. It is not clear whether these arise from distinct populations of channels, or from modulation of a single population. A very slowly inactivating component, [INa(P)] INa(P) is usually about 1% of the size of the peak transient current [INa(T)], but is en...
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