نتایج جستجو برای: immunopathology

تعداد نتایج: 2299  

Journal: :Journal of Autoimmunity 2007

Journal: :Science-Business eXchange 2009

Journal: :iranian journal of allergy, asthma and immunology 0
esmaeil mortaz division of pharmacology, utrecht institute for pharmaceutical sciences, faculty of science, utrecht university, utrecht, the netherlands and chronic respiratory diseases research center and national research institute of tuberculosis and lung diseases (nritld), department of immunology, shahidbeheshti  university of medical sciences, tehran, iran mohammad reza masjedi respiratory diseases research center and national research institute of tuberculosis and lung diseases (nritld), department of immunology, shahidbeheshti university of medical sciences, tehran, iran. payam tabarsi clinical tuberculosis and epidemiology research center, national research institute of tuberculosis and lung diseases (nritld), shahid beheshti university of medical sciences, tehran, iran. mihan pourabdollah chronic respiratory diseases research center and national research institute of tuberculosis and lung diseases (nritld), department of immunology, shahidbeheshti university of medical sciences, tehran, iran. ian m adcock airways disease section, national heart and lung institute, imperial college london, london, uk.

the immunopathology of sarcoidosis remains elusive despite years of research into this multiorgan disease.however, recent studies have provided new insights into the genetics and immune components involved in the clinical manifestation of the disease. granulomatous inflammation is due to the host immune response to a persistent poorly degradable unknown antigen.mycobacterium tuberculosis (mtb) ...

Journal: :Proceedings. Biological sciences 2007
Troy Day Andrea L Graham Andrew F Read

The trade-off hypothesis of virulence evolution rests on the assumption that infection-induced mortality is a consequence of host exploitation by parasites. This hypothesis lies at the heart of many empirical and theoretical studies of virulence evolution, despite growing evidence that infection-induced mortality is very often a by-product of host immune responses. We extend the theoretical fra...

2011
Gráinne H Long Andrea L Graham

Evolutionary theories explaining virulence-the fitness damage incurred by infected hosts-often focus on parasite strategies for within-host exploitation. However, much virulence can be caused by the host's own immune response: for example, pro-inflammatory cytokines, although essential for killing malaria parasites, also damage host tissue. Here we argue that immune-mediated virulence, or 'immu...

Journal: :Proceedings. Biological sciences 2012
Alex Best Gráinne Long Andy White Mike Boots

By definition, parasites harm their hosts, but in many infections much of the pathology is driven by the host immune response rather than through direct damage inflicted by parasites. While these immunopathological effects are often well studied and understood mechanistically in individual disease interactions, there remains relatively little understanding of their broader impact on the evoluti...

Journal: :Memorias do Instituto Oswaldo Cruz 2009
Maximilian Schreiner Oliver Liesenfeld

Small intestinal immunopathology following oral infection with tissue cysts of Toxoplasma gondii has been described in C57BL/6 mice. Seven days after infection, mice develop severe small intestinal necrosis and succumb to infection. The immunopathology is mediated by local overproduction of Th1-type cytokines, a so-called 'cytokine storm'. The immunopathogenesis of this pathology resembles that...

2007
Troy Day Andrea L. Graham Andrew F. Read

Word Count (Main text) ~4700 Abstract The trade-off hypothesis of virulence evolution rests on the assumption that infection-induced mortality is a consequence of host exploitation by parasites. This hypothesis lies at the heart of many empirical and theoretical studies of virulence evolution, despite growing evidence that infection-induced mortality is very often a by-product of host immune re...

Journal: :Journal of immunology 2011
Sarah McCormick Christopher R Shaler Cherrie-Lee Small Carly Horvath Daniela Damjanovic Earl G Brown Naoko Aoki Toshiyuki Takai Zhou Xing

Immunopathology is a major cause of influenza-associated morbidity and mortality worldwide. However, the role and regulatory mechanisms of CD4 T cells in severe lung immunopathology following acute influenza infection are poorly understood. In this paper, we report that the emergence of immunopathogenic CD4 T cells is under the control of a transmembrane immunoadaptor DAP12 pathway during influ...

Journal: :Journal of Tropical Diseases 2016

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