T cells interacting with antigen-presenting cells (APCs) form an "immunological synapse" (IS), a bull's-eye pattern composed of a central supramolecular activation cluster enriched with T cell receptors (TCRs) surrounded by a ring of adhesion molecules (a peripheral supramolecular activation cluster). The mechanism responsible for segregating TCR and adhesion molecules remains poorly understood...

The discovery of the immunological synapse is one of the more striking developments in T cell biology in recent years. The immunological synapse forms at the interface between T cells and antigen-presenting cells (APCs) or target cells. It is characterised by the large-scale segregation of cell surface molecules into concentric zones, forming a bull's eye pattern several microns in diameter (re...

OBJECTIVES The objective was to determine the effect of myofascial techniques on the modulation of immunological variables. DESIGN Thirty-nine healthy male volunteers were randomly assigned to an experimental or control group. INTERVENTIONS The experimental group underwent three manual therapy modalities: suboccipital muscle release, so-called fourth intracranial ventricle compression, and ...

Directed secretion by immune cells requires formation of the immunological synapse at the site of cell-cell contact, concomitant with a dramatic induction of cell polarity. Recent findings provide us with insights into the various steps that are required for these processes: for example, the first identification of a protein at the centrosome that regulates its relocation to the plasma membrane...