conclusions subcutaneous nodules in the absence of a local reaction at the site of bcg vaccination may be the sole manifestation of disseminated bcg disease. case presentation we report on an 11-months-old boy with prolonged fever and diffuse hyperpigmented subcutaneous nodules. due to lymphopenia, oral thrush and severe adverse reaction to bcg vaccination, the possibility of primary immunodefi...

In the August 1,1991 issue ofBlood, San Miguel et all published a report of 41 acute leukemia cases secondary to a myelodysplastic syndrome (MDS). Two were classified as M6 French-AmericanBritish (FAB) subtype on morphologic aspect, but the only erythroid immunologic marker tested, ie, glycophorin A, was negative. This characteristic, owing to the fact that glycophorin A is a relatively mature ...

Introduction We have designed a synthetic peptide-based system for the control of FMD, having synthetic peptide-based NS immunoassays and peptide-based marker vaccines. The UBI system for FMD has two indirect ELISAs for screening animals based on 3B nonstructural protein (NS) synthetic antigen, for detection of animals that may be carrying infectious virus and for differentiation of exposed fro...

the primary immunodeficiency (pi) disorders are abnormalities in development and maturation of the immune system. individuals with pi disease may experience frequent infections, which limit their abilities to exhibit physical and psychological well-being secondary to their illness. in this survey we compared health-related quality of life of primary immune deficient patients with healthy childr...

  Background and Objective: Presence of hepatitis B core antibody (anti-HBc) in the absence of hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) is defined, as isolated anti-HBc. little is known about the clinical significance of the isolated anti-HBc in hepatitis B virus (HBV) infections. The aim of this study was to assess the significance of anti-HBc as the onl...

it has been recognized that acute and chronic stress has an impact on the immune system. acute stress may have a stimulating effect on the immune system, while in the case of chronic stress specially depression, the immune system could be down-regulated. however, an association between depression and a higher number of circulating white blood cells with increased activity has been reported. ele...

Leukemia in the newborn is an infrequent disease that has not been well defined using modern laboratory techniques. We describe two infants, one at birth and one at four weeks, with acute lymphoblastic leukemia. The blasts from each patient were studied in great detail, using a battery of cytochemical and immunologic procedures in addition to ultrastructural studies. Immunologic cell marker stu...

coincidence of autoimmune diseases such as immune thrombocytopenic purpura (itp) with  immunodeficiencies has  been  reported  previously in  patients  who  suffered  from primary antibody deficiency (pad). but there is no original study on immunological profiles of itp patients to find out their probable immune deficiency. in this case-control study, itp patients’ humoral immunity was investig...