نتایج جستجو برای: immune antigen
تعداد نتایج: 431100 فیلتر نتایج به سال:
Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-β1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is ...
Introduction: To date, many vaccines have been developed for anthrax but not yet an ideal vaccine. In this study, chimeric protein containing domain 1 lethal factor and domain 4 protective antigens of Bacillus anthracis in copolymer nanocapsules were used to solve the problems caused by existing vaccines and to increase the efficiency of the proposed vaccine. Materials and Methods: In this expe...
Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...
Background: Tumor cells express antigens that can be recognized by immune system as foreign particles. Heat shock proteins (HSPs) are molecular chaperones that bind to tumor antigens and mediate their uptake into antigen presenting cells. Methods: This articles is a review article and its data has been collected and categorized from the articles in the field of cancer immunotherapy. All the ar...
objective(s): an efficient vaccine against tb is an urgent need. tb peptides are safe candidate but they are weak immunogens and needs to be potentiated by adjuvant/delivery systems. the main purpose of the present study was to determine the potential of cht based nps containing esat-6 antigen of m. tuberculosis for inducing mucosal and systemic immune responses after intranasal and subcutaneou...
the immunosuppressive effect of antimacrophage serum (ams) on the primary immune response of mice to sheep red blood cells (srbc) was studied. ams, given before a small dose of antigen, abrogated the immune response. transplantation of normal, galss-adherent macrophages enabled ams-treated animals to respond to srbc, while administration of lymph node lymphocytes did not reveres ams - induced i...
Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...
objective(s): drug delivery via mucosal routes has been confirmed to be effective in inducing strong immune responses. liposomes could enhance immune responses and mucoadhesive potentials, make them useful mucosal drug delivery systems. coating of liposomes by mucoadhesive polymers succeeded in enhancing immune responses. our studies aim at preparation and characterization of trimethylchitosan-...
background: during antigen capture and processing, mature dendritic cells (dc) express large amounts of peptide-mhc complexes and accessory molecules on their surface. dc are antigen-presenting cells that have an important role in tolerance and autoimmunity. the transforming growth factor-beta1 (tgf-β1) cytokine has a regulatory role on the immune and non-immune cells. the aim of this study is ...
Vaccine adjuvants are immunostimulatory substances used to improve and modulate the immune response induced by antigens. A better understanding of antigen-adjuvant interactions is necessary ...
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