Association between emotionality and effect of imipramine on immobility time in forced swimming test was investigated in Swiss and Balb/c mice. Mice of both the strains were segregated into normal emotional (mean +/- 1SD), low emotional (> mean + 1SD) and high emotional (< mean - 1SD) based on their performance with respect to each indices of emotionality in novel arena and elevated plus maze. ...

Epilepsy is a highly debilitating disorder by unpredictable seizures associated with emotional disturbance. One potential treatment for seizure and depression is dietary therapy. So, this study evaluated effects of daily oral administration of sesame and flaxseed oils in depression and seizure. Twenty-one adult male mice were divided into the following groups: control (normal saline recipient, ...

The forced swim test in rodents has been widely used to evaluate potential effectiveness of antidepressant medications since it was described in 1977 by Porsolt. In this test, a rodent is placed in a water container, and its immobility time is measured. The immobility time indicates the level of inactivity, interpreted as ‘hopelessness’, and has been shown to decrease when the rodent is treated...

vitamin b6 is a cofactor of various enzymes influencing numerous neurotransmitters in the brain such as norepinephrin, and serotonin . since these neurotransmitters influence mood , the aim the present work to evaluate the effect of vitamin b6 on depression and obsessive compulsive behavior when coadministred with clomipramine, fluoxetine, or venlafaxine. male mice weighing 25-30 g were used. t...

in the present study, we have investigated the effects of silymarine on depression and the possible role of serotonergic system in these effects. the rats were anesthetized intraperitoneally with ketamine hydrochloride and placed in a stoelting stereotaxic instrument. a stainless steel guide cannula (22-gauge) was implanted in the third ventricular region. the third ventricular region was infus...

In the current study, the involvement of N-methyl-d-aspartate receptor (NMDAR) and nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) system in the antidepressant-like effects of baclofen was evaluated by using animal model in forced swimming test. Followed by an open field test for the evaluation of locomotor activity, the immobility time for mice in force swimming test was recorded. Only...